C
Christopher R. Vakoc
Researcher at Cold Spring Harbor Laboratory
Publications - 153
Citations - 21315
Christopher R. Vakoc is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Transcription factor & Chromatin. The author has an hindex of 52, co-authored 132 publications receiving 17071 citations. Previous affiliations of Christopher R. Vakoc include University of Pennsylvania & Watson School of Biological Sciences.
Papers
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Journal ArticleDOI
The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer
Eric Wang,Shinpei Kawaoka,Jae Seok Roe,Junwei Shi,Junwei Shi,Anja F. Hohmann,Yali Xu,Yali Xu,Anand S. Bhagwat,Anand S. Bhagwat,Yutaka Suzuki,Justin B. Kinney,Justin B. Kinney,Christopher R. Vakoc +13 more
TL;DR: An essential role for TRIM33 is revealed in preventing apoptosis in B lymphoblastic leukemia by interfering with enhancer-mediated Bim activation and deleting this enhancer renders TRIM 33 dispensable for leukemia cell survival.
Journal ArticleDOI
The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators
Dorothy C.C. Wai,Taylor N. Szyszka,Amy E. Campbell,Cherry Kwong,Lorna Wilkinson-White,Ana P. G. Silva,Jason Low,Ann H. Kwan,Roland Gamsjaeger,James D. Chalmers,Wayne M. Patrick,Bin Lu,Christopher R. Vakoc,Gerd A. Blobel,Joel P. Mackay +14 more
TL;DR: Insight is provided into the mechanisms by which BET family proteins might link chromatin acetylation to transcriptional outcomes and an unexpected functional similarity between BET and YEATS family proteins is uncovered.
Peer ReviewDOI
Author response: Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
Gerard L. Brien,Gerard L. Brien,David Remillard,Junwei Shi,Matthew L. Hemming,Jonathon Chabon,Kieran Wynne,Eugene T. Dillon,Gerard Cagney,Guido van Mierlo,Marijke P. Baltissen,Michiel Vermeulen,Jun Qi,Stefan Fröhling,Stefan Fröhling,Nathanael S. Gray,James E. Bradner,Christopher R. Vakoc,Scott A. Armstrong +18 more
Journal ArticleDOI
Erratum: The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma (Cancer Cell (2018) 33(3) (527–541.e8) (S1535610818300187) (10.1016/j.ccell.2018.01.018))
Ana Banito,Xiang Li,Aimée N. Laporte,Jae Seok Roe,Francisco Sanchez-Vega,Chun-Hao Huang,Amanda R. Dancsok,Katerina Hatzi,Chi-Chao Chen,Darjus F. Tschaharganeh,Rohit Chandwani,Nilgun Tasdemir,Kevin B. Jones,Mario R. Capecchi,Christopher R. Vakoc,Nikolaus Schultz,Marc Ladanyi,Torsten O. Nielsen,Scott W. Lowe +18 more
Journal ArticleDOI
ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer
Tim D.D. Somerville,Yali Xu,Xiaoli S. Wu,Xiaoli S. Wu,Diogo Maia-Silva,Stella K Hur,Larissa M N de Almeida,Jonathan B. Preall,Peter K. Koo,Christopher R. Vakoc +9 more
TL;DR: It is suggested that high ZBED2 expression is acquired during PDA progression to suppress the IFN response pathway and to promote lineage plasticity in this disease.