C
Christopher R. Vakoc
Researcher at Cold Spring Harbor Laboratory
Publications - 153
Citations - 21315
Christopher R. Vakoc is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Transcription factor & Chromatin. The author has an hindex of 52, co-authored 132 publications receiving 17071 citations. Previous affiliations of Christopher R. Vakoc include University of Pennsylvania & Watson School of Biological Sciences.
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Journal ArticleDOI
Brd4 is on the move during inflammation
TL;DR: It is suggested that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome.
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Enhancer dysfunction in leukemia.
TL;DR: The evidence for alterations in enhancer landscapes contributing to the pathogenesis of leukemia, a malignancy in which enhancer-binding proteins and enhancer DNA itself are altered via genetic mutation is reviewed.
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Acquired Dependence of Acute Myeloid Leukemia on the DEAD-Box RNA Helicase DDX5
Anthony Mazurek,Young-Kyu Park,Cornelius Miething,John E. Wilkinson,Jesse Gillis,Scott W. Lowe,Christopher R. Vakoc,Bruce Stillman +7 more
TL;DR: It is reported that AML is dependent on DDX5 and that inhibiting DDx5 expression slows AML cell proliferation in vitro and AML progression in vivo but is not toxic to cells from normal bone marrow, and it is shown thatDDX5 is dispensable for normal hematopoiesis and tissue homeostasis.
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C/EBPα: critical at the origin of leukemic transformation
TL;DR: Roe and Vakoc discuss the role of C/EBPα in the initiation of acute myeloid leukemia and the importance of knowing the carrier and removal status of canine coronavirus in this case.
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Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer
Amanda R. Oran,Clare M. Adams,Xiao-yong Zhang,Victoria J. Gennaro,Harla K. Pfeiffer,Hestia S. Mellert,Hans E. Seidel,Kirsten Mascioli,Jordan Kaplan,Mahmoud R. Gaballa,Chen Shen,Isidore Rigoutsos,Michael P. King,Justin Cotney,Jamie J. Arnold,Suresh D. Sharma,Ubaldo E. Martinez-Outschoorn,Christopher R. Vakoc,Lewis A. Chodosh,James E. Thompson,James E. Bradner,Craig E. Cameron,Gerald S. Shadel,Christine M. Eischen,Steven B. McMahon +24 more
TL;DR: It is demonstrated that inhibition of this newly defined MYC effector pathway causes robust and selective tumor cell apoptosis, via an acute, checkpoint-like mechanism linked to aberrant electron transport chain complex assembly and mitochondrial reactive oxygen species (ROS) production.