C
Christopher R. Vakoc
Researcher at Cold Spring Harbor Laboratory
Publications - 153
Citations - 21315
Christopher R. Vakoc is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Transcription factor & Chromatin. The author has an hindex of 52, co-authored 132 publications receiving 17071 citations. Previous affiliations of Christopher R. Vakoc include University of Pennsylvania & Watson School of Biological Sciences.
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Journal ArticleDOI
ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization.
Fei Li,Fei Li,Zhong Deng,Ling Zhang,Ling Zhang,Caizhi Wu,Ying Jin,Inah Hwang,Olga Vladimirova,Libo Xu,Libo Xu,Lynnie Yang,Bin Lu,Javaraju Dheekollu,J. Li,Hua Feng,Jian Hu,Christopher R. Vakoc,Haoqiang Ying,Jihye Paik,Paul M. Lieberman,Hongwu Zheng,Hongwu Zheng +22 more
TL;DR: It is shown that endogenous telomerase activity cannot overcome telomere dysfunction induced by ATRX loss, leaving telomeres repair‐based ALT as the only viable mechanism forTelomere maintenance during immortalization, and implicate ALT activation as an adaptive response to ATRx/DAXX loss‐induced telomer replication dysfunction.
Journal ArticleDOI
Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Erin R. Aho,Jing Wang,Rocco D. Gogliotti,Gregory C. Howard,Jason Phan,Pankaj Acharya,Jonathan David Macdonald,Kenneth Cheng,Shelly L. Lorey,Bin Lu,Sabine Wenzel,Audra M. Foshage,Joseph Alvarado,Feng Wang,J.G. Shaw,Bin Zhao,April M. Weissmiller,Lance R. Thomas,Christopher R. Vakoc,Hall,Scott W. Hiebert,Qi Liu,Shaun R. Stauffer,Stephen W. Fesik,William P. Tansey +24 more
TL;DR: It is demonstrated that the WIN site links WDR5 to chromatin at a small cohort of loci, including a specific subset of ribosome protein genes, which means that WIN site blockade could have utility against multiple cancer types.
Journal ArticleDOI
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer.
Tobiloba E. Oni,Tobiloba E. Oni,Tobiloba E. Oni,Giulia Biffi,Giulia Biffi,Giulia Biffi,Lindsey A. Baker,Lindsey A. Baker,Yuan Hao,Claudia Tonelli,Claudia Tonelli,Tim D.D. Somerville,Astrid Deschênes,Astrid Deschênes,Pascal Belleau,Chang-Il Hwang,Chang-Il Hwang,Chang-Il Hwang,Francisco J. Sánchez-Rivera,Hilary Cox,Erin Brosnan,Erin Brosnan,Abhishek Doshi,Abhishek Doshi,Rebecca P. Lumia,Rebecca P. Lumia,Kimia Khaledi,Kimia Khaledi,Young-Kyu Park,Young-Kyu Park,Lloyd C. Trotman,Scott W. Lowe,Alexander Krasnitz,Christopher R. Vakoc,David A. Tuveson,David A. Tuveson +35 more
TL;DR: This study reveals how pancreatic cancer cells hyperactivate a pathway to sustain their proliferation, and inhibits this pathway affects cancer cells, but not normal cells, highlighting a new therapeutic opportunity.
Journal ArticleDOI
A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia
Yali Xu,Yali Xu,Joseph P. Milazzo,Tim D.D. Somerville,Yusuke Tarumoto,Yu-Han Huang,Elizabeth L. Ostrander,John E. Wilkinson,Grant A. Challen,Christopher R. Vakoc +9 more
TL;DR: This study reveals a strategy for potent MYB inhibition in AML and highlights how an oncogenic TF can be selectively neutralized by targeting a general coactivator complex.
Journal ArticleDOI
Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Qiang Zhang,Lei Zeng,Lei Zeng,Chen Shen,Ying Ju,Tsuyoshi Konuma,Chengcheng Zhao,Christopher R. Vakoc,Ming-Ming Zhou +8 more
TL;DR: It is reported that the ET domain of the BET protein BRD4 recognizes an amphipathic protein sequence motif through establishing a two-strand antiparallel β sheet anchored on a hydrophobic cleft of the three-helix bundle.