C
Christopher R. Vakoc
Researcher at Cold Spring Harbor Laboratory
Publications - 153
Citations - 21315
Christopher R. Vakoc is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Transcription factor & Chromatin. The author has an hindex of 52, co-authored 132 publications receiving 17071 citations. Previous affiliations of Christopher R. Vakoc include University of Pennsylvania & Watson School of Biological Sciences.
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Journal ArticleDOI
The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
Junwei Shi,Christopher R. Vakoc +1 more
TL;DR: The current understanding of molecular mechanisms that underlie the promising therapeutic effects of BET bromodomain inhibition are reviewed.
Journal ArticleDOI
Organoid profiling identifies common responders to chemotherapy in pancreatic cancer
Hervé Tiriac,Pascal Belleau,Dannielle D. Engle,Dennis Plenker,Astrid Deschênes,Tim D.D. Somerville,Fieke E. M. Froeling,Richard A. Burkhart,Robert E. Denroche,Gun-Ho Jang,Koji Miyabayashi,C. Megan Young,C. Megan Young,Hardik Patel,Michelle Ma,Joseph F. LaComb,Randze Lerie Palmaira,Ammar A. Javed,Jasmine Huynh,Molly E. Johnson,Kanika Arora,Nicolas Robine,Minita Shah,Rashesh Sanghvi,Austin Goetz,Cinthya Y. Lowder,Laura A. Martello,Else Driehuis,Nicolas Lecomte,Gokce Askan,Christine A. Iacobuzio-Donahue,Hans Clevers,Laura D. Wood,Ralph H. Hruban,Elizabeth D. Thompson,Andrew J. Aguirre,Brian M. Wolpin,Aaron R. Sasson,Joseph Kim,Maoxin Wu,Juan Carlos Bucobo,Peter J. Allen,Divyesh V. Sejpal,William Nealon,James Sullivan,Jordan M. Winter,Phyllis A. Gimotty,Jean L. Grem,Dominick J. DiMaio,Jonathan M. Buscaglia,Paul M. Grandgenett,Jonathan R. Brody,Michael A. Hollingsworth,Grainne M. O'Kane,Faiyaz Notta,Edward J. Kim,James M. Crawford,Craig Devoe,Allyson J. Ocean,Christopher L. Wolfgang,Kenneth H. Yu,Ellen Li,Christopher R. Vakoc,Benjamin Hubert,Sandra Fischer,Sandra Fischer,Julie M. Wilson,Richard A. Moffitt,Jennifer J. Knox,Alexander Krasnitz,Steven Gallinger,Steven Gallinger,Steven Gallinger,David A. Tuveson +73 more
TL;DR: A pancreatic cancer patient-derived organoid (PDO) library is generated that recapitulates the mutational spectrum and transcriptional subtypes of primary Pancreatic cancer and proposes that combined molecular and therapeutic profiling of PDOs may predict clinical response and enable prospective therapeutic selection.
Journal ArticleDOI
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
TL;DR: It is shown that the magnitude of negative selection can be used to infer the functional importance of individual protein domains of interest, and a broader application of this approach may allow comprehensive identification of protein domains that sustain cancer cells and are suitable for drug targeting.
Journal ArticleDOI
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.
Charles M. Rudin,John T. Poirier,Lauren Averett Byers,Caroline Dive,Afshin Dowlati,Julie George,John V. Heymach,Jane E. Johnson,Jonathan M. Lehman,David MacPherson,Pierre P. Massion,John D. Minna,Trudy G. Oliver,Vito Quaranta,Julien Sage,Roman K. Thomas,Christopher R. Vakoc,Adi F. Gazdar +17 more
TL;DR: This Opinion, written by many leading experts in small cell lung cancer (SCLC) research, proposes a new model of SCLC subtypes defined by differential expression of four key transcription regulators that should help to focus and accelerate therapeutic research.
Journal ArticleDOI
Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1
Christopher R. Vakoc,Danielle L. Letting,Danielle L. Letting,Nele Gheldof,Tomoyuki Sawado,M. A. Bender,Mark Groudine,Mitchell J. Weiss,Mitchell J. Weiss,Job Dekker,Gerd A. Blobel,Gerd A. Blobel +11 more
TL;DR: Using chromosome conformation capture (3C), it is shown that the hematopoietic transcription factor GATA-1 and its cofactor FOG-1 are required for the physical interaction between the beta-globin locus control region (LCR) and thebeta-major globin promoter.