C
Christopher R. Vakoc
Researcher at Cold Spring Harbor Laboratory
Publications - 153
Citations - 21315
Christopher R. Vakoc is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Transcription factor & Chromatin. The author has an hindex of 52, co-authored 132 publications receiving 17071 citations. Previous affiliations of Christopher R. Vakoc include University of Pennsylvania & Watson School of Biological Sciences.
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Journal ArticleDOI
Insights into pediatric rhabdomyosarcoma research: Challenges and goals
Marielle E. Yohe,Christine M. Heske,Elizabeth Stewart,Peter C. Adamson,Nabil Ahmed,Cristina R. Antonescu,Eleanor Y. Chen,Natalie Collins,Alan R. Ehrlich,Rene L. Galindo,Berkley E. Gryder,Heidi Hahn,Sharon Hammond,Mark E. Hatley,Douglas S. Hawkins,Madeline N. Hayes,Andrea Hayes-Jordan,Lee J. Helman,Simone Hettmer,Myron S. Ignatius,Charles Keller,Javed Khan,David G. Kirsch,Corinne M. Linardic,Philip J. Lupo,Rossella Rota,Jack F. Shern,Janet Shipley,Sivasish Sindiri,Stephen J. Tapscott,Christopher R. Vakoc,Leonard H. Wexler,David M. Langenau +32 more
TL;DR: This work proposes streamlining the process by which agents are selected for clinical evaluation in RMS, and believes that strong consideration should be given to the development of combination therapies that add biologically targeted agents to conventional cytotoxic drugs.
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The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma
Narendra Bharathy,Noah E. Berlow,Eric Wang,Jinu Abraham,Teagan P. Settelmeyer,Jody E. Hooper,Matthew N. Svalina,Yoshihiro Ishikawa,Keith D. Zientek,Zia Bajwa,Martin Goros,Brian Hernandez,Johannes E. A. Wolff,Michelle A. Rudek,Linping Xu,Nicole M. Anders,Ranadip Pal,Alexandria P. Harrold,Angela M Davies,Arya Ashok,Darnell Bushby,Maria Cecilia Mancini,Christopher J. Noakes,Neal Goodwin,Peter Ordentlich,James G. Keck,Douglas S. Hawkins,Erin R. Rudzinski,Bishwanath Chatterjee,Hans Peter Bächinger,Hans Peter Bächinger,Frederic G. Barr,Jennifer C. Liddle,Benjamin A. Garcia,Atiya Mansoor,Theodore J. Perkins,Theodore J. Perkins,Christopher R. Vakoc,Joel E. Michalek,Charles Keller +39 more
TL;DR: An HDAC3–SMARCA4–miR-27a–PAX3:FOXO1 circuit as a driver of chemoresistant aRMS and suggest that targeting this pathway with entinostat may be therapeutically effective in patients is suggested.
Journal ArticleDOI
Salt-Inducible Kinase inhibition suppresses acute myeloid leukemia progression in vivo
Yusuke Tarumoto,Yusuke Tarumoto,Shan Lin,Shan Lin,Jinhua Wang,Joseph P. Milazzo,Yali Xu,Bin Lu,Zhaolin Yang,Yiliang Wei,Sofya A. Polyanskaya,Sofya A. Polyanskaya,Mark Wunderlich,Nathanael S. Gray,Kimberly Stegmaier,Kimberly Stegmaier,Christopher R. Vakoc +16 more
TL;DR: These findings validate Sik3 as a therapeutic target in MEF2C-addicted AML and provide a rationale for developing drug-like inhibitors of SIK3 for definitive pre-clinical investigation and for studies in human patients.
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MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Anna Skucha,Jessica Ebner,Johannes Schmöllerl,Mareike Roth,Thomas Eder,Adrián César-Razquin,Alexey Stukalov,Sarah Vittori,Matthias Muhar,Bin Lu,Martin Aichinger,Julian Jude,André C. Müller,Balázs Győrffy,Christopher R. Vakoc,Peter Valent,Keiryn L. Bennett,Johannes Zuber,Giulio Superti-Furga,Giulio Superti-Furga,Florian Grebien +20 more
TL;DR: A dependency of MLL-leukemia cells on the methyltransferase SETD2 to maintain genomic integrity during leukemia initiation and maintenance is described, revealing a novel actionable vulnerability in this disease.
Journal ArticleDOI
Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin.
TL;DR: H3K9 methylation and HP1γ not only function in repressive chromatin, but play a novel and unexpected role during transcription activation, which further elucidate new combinations of histone modifications that distinguish between repressed and actively transcribing chromatin.