C
Christopher R. Vakoc
Researcher at Cold Spring Harbor Laboratory
Publications - 153
Citations - 21315
Christopher R. Vakoc is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Transcription factor & Chromatin. The author has an hindex of 52, co-authored 132 publications receiving 17071 citations. Previous affiliations of Christopher R. Vakoc include University of Pennsylvania & Watson School of Biological Sciences.
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Journal ArticleDOI
Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus
Huie Jing,Christopher R. Vakoc,Lei Ying,Sean A. Mandat,Hongxin Wang,Xingwu Zheng,Gerd A. Blobel,Gerd A. Blobel +7 more
TL;DR: This work shows that a GATA factor exchange reconfigures higher-order chromatin organization, and suggests that de novo chromatin loop formation is employed by nuclear factors to specify repressive outcomes.
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Jake Delmore,Ghayas C Issa,Madeleine E. Lemieux,Peter B. Rahl,Junwei Shi,Hannah M. Jacobs,Efstathios Kastritis,Timothy Gilpatrick,Ronald M. Paranal,Jun Qi,Marta Chesi,Anna C. Schinzel,Michael R. McKeown,Timothy P. Heffernan,Christopher R. Vakoc,P. Leif Bergsagel,Irene M. Ghobrial,Paul G. Richardson,Richard A. Young,William C. Hahn,William C. Hahn,Kenneth C. Anderson,Andrew L. Kung,James E. Bradner,Constantine S. Mitsiades +24 more
TL;DR: Efficacy of JQ1 in three murine models of multiple myeloma establishes the therapeutic rationale for BET bromodomain inhibition in this disease and other malignancies characterized by pathologic activation of c-Myc.
Journal ArticleDOI
Mammalian ASH1L Is a Histone Methyltransferase That Occupies the Transcribed Region of Active Genes
Gregory D. Gregory,Christopher R. Vakoc,Christopher R. Vakoc,Tanya Rozovskaia,Xingwu Zheng,Shetal A. Patel,Shetal A. Patel,Tatsuya Nakamura,Eli Canaani,Gerd A. Blobel,Gerd A. Blobel +10 more
TL;DR: The data suggest that ASH1L occupies most, if not all, active genes and methylates histone H3 in a nonredundant fashion at a subset of genes.
Journal ArticleDOI
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes.
Tamara Tripic,Wulan Deng,Wulan Deng,Yong Cheng,Ying Zhang,Christopher R. Vakoc,Gregory D. Gregory,Ross C. Hardison,Gerd A. Blobel,Gerd A. Blobel +9 more
TL;DR: The SCL complex is identified as a critical and consistent determinant of positive GATA-1 activity in multiple Gata-1-regulated hematopoietic cell lineages.
Journal ArticleDOI
A Reconfigured Pattern of MLL Occupancy within Mitotic Chromatin Promotes Rapid Transcriptional Reactivation Following Mitotic Exit
Gerd A. Blobel,Stephan Kadauke,Eric Wang,Alan W. Lau,Johannes Zuber,Margaret M. Chou,Christopher R. Vakoc +6 more
TL;DR: Findings implicate mitotic bookmarking as a component of Trithorax-based gene regulation, which may facilitate inheritance of active gene expression states during cell division, and is dispensable for preserving histone H3K4 methylation.