C
Cindy J.M. Loomans
Researcher at Leiden University Medical Center
Publications - 14
Citations - 2180
Cindy J.M. Loomans is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Progenitor cell & Pancreas. The author has an hindex of 13, co-authored 14 publications receiving 1980 citations. Previous affiliations of Cindy J.M. Loomans include Utrecht University & Harvard University.
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Journal ArticleDOI
Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes
Cindy J.M. Loomans,Eelco J.P. de Koning,Frank J. T. Staal,Maarten B. Rookmaaker,C. Verseyden,Hetty C. de Boer,Marianne C. Verhaar,Branko Braam,Ton J. Rabelink,Anton Jan van Zonneveld +9 more
TL;DR: It is demonstrated that adverse metabolic stress factors in type 1 diabetes are associated with reduced EPC numbers and angiogenicity, and hypothesize that EPC dysfunction contributes to the pathogenesis of vascular complications intype 1 diabetes.
Journal ArticleDOI
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
Meritxell Huch,Paola Bonfanti,Sylvia F. Boj,Toshiro Sato,Cindy J.M. Loomans,Cindy J.M. Loomans,Marc van de Wetering,Mozhdeh Sojoodi,Vivian S. W. Li,Jurian Schuijers,Ana Gracanin,Femke Ringnalda,Femke Ringnalda,Harry Begthel,Karien Hamer,Joyce Mulder,Johan H. van Es,Eelco J.P. de Koning,Eelco J.P. de Koning,Robert G.J. Vries,Harry Heimberg,Hans Clevers +21 more
TL;DR: It is reported that the Wnt pathway is robustly activated upon injury by partial duct ligation (PDL), concomitant with the appearance of Lgr5 expression in regenerating pancreatic ducts.
Journal ArticleDOI
Intravital Microscopy Through an Abdominal Imaging Window Reveals a Pre-Micrometastasis Stage During Liver Metastasis
Laila Ritsma,Ernst J.A. Steller,Evelyne Beerling,Cindy J.M. Loomans,Anoek Zomer,Carmen Gerlach,Nienke Vrisekoop,Danielle Seinstra,Léon van Gurp,Ronny Schäfer,Danielle A.E. Raats,Anko M. de Graaff,Ton N. Schumacher,Eelco J.P. de Koning,Eelco J.P. de Koning,Inne H.M. Borel Rinkes,Onno Kranenburg,Jacco van Rheenen +17 more
TL;DR: The preliminary findings suggest a new target for pharmacological inhibition of cancer growth and migration, and additional preclinical and clinical studies will be needed to follow up this pre-micrometastatic hypothesis and to further confirm its presence in humans.
Journal ArticleDOI
Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential
Cindy J.M. Loomans,Cindy J.M. Loomans,Nerys Williams Giuliani,Nerys Williams Giuliani,Jeetindra R A Balak,Femke Ringnalda,Léon van Gurp,Meritxell Huch,Meritxell Huch,Sylvia F. Boj,Toshiro Sato,Lennart Kester,Susana M. Chuva de Sousa Lopes,Matthias S Roost,Susan Bonner-Weir,Marten A. Engelse,Ton J. Rabelink,Harry Heimberg,Robert G.J. Vries,Alexander van Oudenaarden,Françoise Carlotti,Hans Clevers,Eelco J.P. de Koning,Eelco J.P. de Koning +23 more
TL;DR: It is concluded that adult human pancreatic tissue has potential for expansion into 3D structures harboring progenitor cells with endocrine differentiation potential.
Journal ArticleDOI
Differentiation of bone marrow-derived endothelial progenitor cells is shifted into a proinflammatory phenotype by hyperglycemia.
Cindy J.M. Loomans,Cindy J.M. Loomans,Rien van Haperen,Jacques M.G.J. Duijs,C. Verseyden,Rini de Crom,Pieter J. M. Leenen,Hemmo A. Drexhage,Hetty C. de Boer,Eelco J.P. de Koning,Ton J. Rabelink,Frank J. T. Staal,Anton Jan van Zonneveld +12 more
TL;DR: The study results show that hyperglycemia alters the differentiation fate of BM precursor cells, reducing the potential to generate vascular regenerative cells and favoring the development of proinflammatory cells.