Claude Ostermann

TL;DR: This work presents a de novo branching cascades approach wherein simple primary substrates follow different cascade reactions to create various distinct molecular frameworks in a scaffold diversity phase, highlighting the immense potential of cascade reactionsto deliver compound libraries enriched in structural and functional diversity.

TL;DR: It is shown that chromopynones define a glucose uptake inhibitor chemotype that selectively targets glucose transporters GLUT-1 and -3, inhibits cancer cell growth and promises to inspire new drug discovery programmes aimed at tumour metabolism.

TL;DR: Pyrano‐furo‐pyridone‐ and dihydropyran NP fragments in three isomeric arrangements are described, which reveal that PFPs induce formation of reactive oxygen species and are structurally novel inhibitors of mitochondrial complex I.

TL;DR: The design, synthesis, and biological evaluation of a collection of indomorphan pseudo‐NPs that combine biosynthetically unrelated indole‐ and morphan‐alkaloid fragments are described and underscore the importance of dual GLUT‐1 andGLUT‐3 inhibition to efficiently suppress tumor cell growth and the cellular rescue mechanism, which counteracts glucose scarcity.

TL;DR: A modified version of diversity selection, which is term Maximum-Score Diversity Selection, that additionally takes the estimated or predicted activities of the molecules into account and validates these theoretical differences on several data sets.