C
Claudio Meneses
Researcher at National Institutes of Health
Publications - 39
Citations - 1249
Claudio Meneses is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Leishmania & Leishmania major. The author has an hindex of 16, co-authored 37 publications receiving 937 citations.
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Journal ArticleDOI
Gut Microbes Egested during Bites of Infected Sand Flies Augment Severity of Leishmaniasis via Inflammasome-Derived IL-1β
Ranadhir Dey,Amritanshu B. Joshi,Fabiano Oliveira,Lais Pereira,Lais Pereira,Anderson B. Guimarães-Costa,Tiago D. Serafim,Waldionê de Castro,Iliano V. Coutinho-Abreu,Parna Bhattacharya,Shannon Townsend,Hamide Aslan,Alec Perkins,Subir Karmakar,Nevien Ismail,Morgan Karetnick,Claudio Meneses,Robert Duncan,Hira L. Nakhasi,Jesus G. Valenzuela,Shaden Kamhawi +20 more
TL;DR: It is demonstrated that gut microbes from the sand fly are egested into host skin alongside Leishmania parasites, indicating that both gut microbiota and IL-1β are important for the establishment of Leishmaniasis infections.
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A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates
Fabiano Oliveira,Edgar Rowton,Hamide Aslan,Regis Gomes,Regis Gomes,Philip A. Castrovinci,Patricia H. Alvarenga,Maha Abdeladhim,Clarissa Teixeira,Clarissa Teixeira,Claudio Meneses,Lindsey T. Kleeman,Anderson B. Guimarães-Costa,Tobin Rowland,Dana C. Gilmore,Seydou Doumbia,Steven G. Reed,Phillip G. Lawyer,John F. Andersen,Shaden Kamhawi,Jesus G. Valenzuela +20 more
TL;DR: It is demonstrated that a vaccine against sand fly salivary protein can protect nonhuman primate from leishmania infection and PdSP15 sequence and structure show no homology to mammalian proteins, further demonstrating its potential as a component of a vaccine for human leishmaniasis.
Journal ArticleDOI
Sequential blood meals promote Leishmania replication and reverse metacyclogenesis augmenting vector infectivity.
Tiago D. Serafim,Iliano V. Coutinho-Abreu,Fabiano Oliveira,Claudio Meneses,Shaden Kamhawi,Jesus G. Valenzuela +5 more
TL;DR: It is shown that ingestion of a second uninfected blood meal by Leishmania-infected sand flies triggers dedifferentiation of metacyclic promastigotes to a replicative form, termed the retroleptomonad promastsigote, which amplifies parasite numbers in the flies.
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The Gut Microbiome of the Vector Lutzomyia longipalpis Is Essential for Survival of Leishmania infantum
Patrick H. Kelly,Sarah M. Bahr,Tiago D. Serafim,Nadim J. Ajami,Joseph F. Petrosino,Claudio Meneses,John R. Kirby,Jesus G. Valenzuela,Shaden Kamhawi,Mary E. Wilson,Mary E. Wilson +10 more
TL;DR: It is suggested that the sand fly midgut microbiome is a critical factor for Leishmania growth and differentiation to its infective state prior to disease transmission, and the possibility that impairing the microbial composition within the vector might represent a novel approach to control of vector-borne diseases.
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Characterization of a Leishmania stage‐specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence
TL;DR: Results demonstrate that Ldp27 is an important component of an active COX complex enhancing oxidative phosphorylation specifically in infectious metacyclics and amastigotes and promoting parasite survival in the host.