Claudius Jacobshagen

TL;DR: Patients with takotsubo cardiomyopathy had a higher prevalence of neurologic or psychiatric disorders than did those with an acute coronary syndrome and physical triggers, acute neurologics or psychiatric diseases, high troponin levels, and a low ejection fraction on admission were independent predictors for in-hospital complications.

TL;DR: It is concluded that CaMKII associates with and phosphorylates cardiac Na(+) channels and alters I( Na) gating to reduce availability at high heart rate, while enhancing late I(Na) (which could prolong action potential duration) in mice.

TL;DR: The trial shows that early de-escalation of antiplatelet treatment can be considered as an alternative approach in patients with acute coronary syndrome managed with PCI and was non-inferior to standard treatment with prasugrel at 1 year after PCI.

TL;DR: The present trial, characterized by low event rates, did not observe a significant difference in net clinical outcome between 6 and 12 months of clopidogrel therapy after DES implantation, but the results of the trial must be considered in view of its premature termination and lower than expected event rates.

TL;DR: In patients with CS, the time elapsing from the first medical contact to primary PCI is a strong predictor of an adverse outcome, hence special efforts to shorten contact-to-balloon time should be applied in particular to these high-risk STEMI patients.