C
Clive Wood
Researcher at Genetics Institute, Inc.
Publications - 76
Citations - 12452
Clive Wood is an academic researcher from Genetics Institute, Inc.. The author has contributed to research in topics: Receptor & Antibody. The author has an hindex of 27, co-authored 76 publications receiving 11392 citations. Previous affiliations of Clive Wood include Brigham and Women's Hospital & MedImmune.
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Journal ArticleDOI
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Gordon J. Freeman,Andrew J. Long,Yoshiko Iwai,Karen Bourque,Tatyana Chernova,Hiroyuki Nishimura,Lori Fitz,Nelly Malenkovich,Taku Okazaki,Michael C. Byrne,Heidi F. Horton,Lynette A. Fouser,Laura L. Carter,Vincent Ling,Michael R Bowman,Beatriz M. Carreno,Mary Collins,Clive Wood,Tasuku Honjo +18 more
TL;DR: It is reported here that the ligand of PD-1 (PD-L1), an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells, is a member of the B7 gene family.
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PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Yvette Latchman,Clive Wood,Tatyana Chernova,Divya Chaudhary,Madhuri Borde,Irene Chernova,Yoshiko Iwai,Andrew J. Long,Julia A. Brown,Raquel A. Nunes,Edward A. Greenfield,Karen Bourque,Vassiliki A. Boussiotis,Laura L. Carter,Beatriz M. Carreno,Nelly Malenkovich,Hiroyuki Nishimura,Taku Okazaki,Tasuku Honjo,Arlene H. Sharpe,Gordon J. Freeman +20 more
TL;DR: These studies show overlapping functions of PD-L1 andPD-L2 and indicate a key role for the PD- L–PD-1 pathway in regulating T cell responses.
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Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production
Julia A. Brown,David M. Dorfman,Feng-Rong Ma,Elizabeth L. Sullivan,Oliver Munoz,Clive Wood,Edward A. Greenfield,Gordon J. Freeman +7 more
TL;DR: It is shown that blockade of PD-L2 on dendritic cells results in enhanced T cell proliferation and cytokine production, including that of IFN-γ and IL-10, which is consistent with the hypothesis that iDC have a balance of stimulatory vs inhibitory molecules that favors inhibition.
Journal ArticleDOI
PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2
Laura L. Carter,Lynette A. Fouser,Jason Jussif,Lori Fitz,Bija Deng,Clive Wood,Mary Collins,Tasuku Honjo,Gordon J. Freeman,Beatriz M. Carreno +9 more
TL;DR: Examination of the functional consequences of PD‐1:PD‐L engagement on murine CD4 and CD8 T cells shows that these interactions result in inhibition of proliferation and cytokine production, and suggests that CD8+ T cells may be more sensitive to modulation by the PD‐ 1: PD‐L pathway because of their intrinsic inability to produce significant levels of IL‐2.
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PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
Kelly-Ann Sheppard,Lori Fitz,Julie M. Lee,Christina Benander,Judith A. George,Joe Wooters,Yongchang Qiu,Jason Jussif,Laura L. Carter,Clive Wood,Divya Chaudhary +10 more
TL;DR: It is demonstrated that PD‐1 modulation of T‐cell function involves inhibition of TCR‐mediated phosphorylation of ZAP70 and association with CD3ζ andPD‐1 signaling attenuates PKCθ activation loop phosphorylated in a cognate TCR signal.