Clive Wood

TL;DR: It is reported here that the ligand of PD-1 (PD-L1), an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells, is a member of the B7 gene family.

TL;DR: These studies show overlapping functions of PD-L1 andPD-L2 and indicate a key role for the PD- L–PD-1 pathway in regulating T cell responses.

TL;DR: It is shown that blockade of PD-L2 on dendritic cells results in enhanced T cell proliferation and cytokine production, including that of IFN-γ and IL-10, which is consistent with the hypothesis that iDC have a balance of stimulatory vs inhibitory molecules that favors inhibition.

TL;DR: Examination of the functional consequences of PD‐1:PD‐L engagement on murine CD4 and CD8 T cells shows that these interactions result in inhibition of proliferation and cytokine production, and suggests that CD8+ T cells may be more sensitive to modulation by the PD‐ 1: PD‐L pathway because of their intrinsic inability to produce significant levels of IL‐2.

TL;DR: It is demonstrated that PD‐1 modulation of T‐cell function involves inhibition of TCR‐mediated phosphorylation of ZAP70 and association with CD3ζ andPD‐1 signaling attenuates PKCθ activation loop phosphorylated in a cognate TCR signal.