C
Cyril Berthet
Researcher at French Institute of Health and Medical Research
Publications - 30
Citations - 3124
Cyril Berthet is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Cell cycle & Cyclin-dependent kinase. The author has an hindex of 24, co-authored 26 publications receiving 2934 citations. Previous affiliations of Cyril Berthet include National Institutes of Health & Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
Cdk2 knockout mice are viable.
TL;DR: Although Cdk2 is not an essential gene in the mouse, it is required for germ cell development and meiosis, suggesting that Cdk 2 is involved in regulating progression through the mitotic cell cycle.
Journal ArticleDOI
Identification of BTG2, an antiproliferative p53–dependent component of the DNA damage cellular response pathway
Jean-Pierre Rouault,Nicole Falette,Fabienne Guehenneux,Céline Guillot,Ruth Rimokh,Qing Wang,Cyril Berthet,Caroline Moyret-Lalle,Pierre Savatier,Bertrand Pain,Philip Shaw,Roland Berger,Jacques Samarut,Jean-Pierre Magaud,Mehmet Ozturk,Mehmet Ozturk,Christiane Samarut,Alain Puisieux +17 more
TL;DR: It is shown that BTG2 expression is induced through a p53-depen-dent mechanism and thatBTG2 function may be relevant to cell cycle control and cellular response to DNA damage.
Journal ArticleDOI
Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer.
Sylvia Julien,Ana Merino-Trigo,Ludovic Lacroix,Marc Pocard,Diane Goéré,Pascale Mariani,Sophie Landron,Ludovic Bigot,Fariba Nemati,Peggy Dartigues,Louis-Bastien Weiswald,Denis Lantuas,Loïc Morgand,Emmanuel Pham,Patrick Gonin,Virginie Dangles-Marie,Bastien Job,Philippe Dessen,Alain Bruno,Alain Pierré,Hany Soliman,Manoel Nunes,Guillaume Lardier,Loreley Calvet,Brigitte Demers,Gregoire Prevost,Patricia Vrignaud,Sergio Roman-Roman,Olivier Duchamp,Cyril Berthet +29 more
TL;DR: An extensive in vivo analysis of patient-derived xenograft models for CRC shows the loss of human stroma cells after engraftment, observed a metastatic phenotype in some models, and compared the molecular profile with the drug sensitivity of each tumor model.
Journal ArticleDOI
In search of a function for the TIS21/PC3/BTG1/TOB family.
TL;DR: It is proposed here to use a nomenclature APRO as a new term for the Btg family of anti‐proliferative gene products, emerging that every member of this family has a potential to regulate cell growth.
Journal ArticleDOI
Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation
Cyril Berthet,Kimberly D. Klarmann,Mary Beth Hilton,Hyung Chan Suh,Jonathan R. Keller,Hiroaki Kiyokawa,Philipp Kaldis +6 more
TL;DR: It is demonstrated that Cdk2 and Cdk4 cooperate to phosphorylate Rb in vivo and to couple the G1/S phase transition to mitosis via E2F-dependent regulation of gene expression.