D
Dale Frank
Researcher at University of Pennsylvania
Publications - 49
Citations - 2244
Dale Frank is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Gene & Genomic imprinting. The author has an hindex of 21, co-authored 44 publications receiving 1980 citations. Previous affiliations of Dale Frank include Columbia University & Columbia University Medical Center.
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Journal ArticleDOI
International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease
David C. Fajgenbaum,Thomas S. Uldrick,Adam Bagg,Dale Frank,David Wu,Gordan Srkalovic,David Simpson,Amy Y. Liu,David M. Menke,Shanmuganathan Chandrakasan,Mary Jo Lechowicz,Raymond S.M. Wong,Sheila K Pierson,Michele Paessler,Jean François Rossi,Makoto Ide,Jason R. Ruth,Michael P. Croglio,Alexander Suarez,Vera P. Krymskaya,Amy Chadburn,Gisele W. B. Colleoni,Sunita D. Nasta,Raj Jayanthan,Christopher S. Nabel,Corey Casper,Angela Dispenzieri,Alexander Fosså,Dermot Kelleher,Razelle Kurzrock,Peter M. Voorhees,Ahmet Dogan,Kazuyuki Yoshizaki,Frits van Rhee,Eric Oksenhendler,Elaine S. Jaffe,Kojo S.J. Elenitoba-Johnson,Megan S. Lim +37 more
TL;DR: The proposed consensus criteria will facilitate consistent diagnosis, appropriate treatment, and collaborative research and exclude infectious, malignant, and autoimmune disorders that can mimic iMCD.
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Placental overgrowth in mice lacking the imprinted gene Ipl.
Dale Frank,Weiwei Fortino,Lorraine N. Clark,Raymond Musalo,Wenxian Wang,Anjana Saxena,C.W. Li,Wolf Reik,Thomas Ludwig,Benjamin Tycko +9 more
TL;DR: Results show a nonredundant function for Ipl in restraining placental growth and indicate that Ipl can act, at least in part, independently of insulin-like growth factor-2 signaling, which regulates multiple pathways to control placental size.
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Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.
TL;DR: Competition between these two molecules may determine the final degree of muscle formation in the marginal zone, thus defining the border between dorsolateral and ventral mesoderm.
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The IPL Gene on Chromosome 11p15.5 is Imprinted in Humans and Mice and is Similar to TDAG51, Implicated in Fas Expression and Apoptosis
Naifeng Qian,Dale Frank,Denise S. O'Keefe,Diem Dao,Long Zhao,Luwa Yuan,Qing Wang,Mark T. Keating,Colum P. Walsh,Benjamin Tycko +9 more
TL;DR: The cloning and characterization of the IPL gene is described, which shows tissue-specific expression and functional imprinting, with the maternal allele active and the paternal allele relatively inactive, in many human and mouse tissues.
Journal ArticleDOI
Placental growth retardation due to loss of imprinting of Phlda2
Martha Salas,Rosalind M. John,Anjana Saxena,Sheila C. Barton,Dale Frank,Galina V. Fitzpatrick,Michael J. Higgins,Benjamin Tycko +7 more
TL;DR: Phlda2 acts as a true rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting, as well as significant placental stunting in BAC-transgenic mice that over-expressed Phlda2 and one flanking gene, Slc22a1l, but did not over-express Cdkn1c.