D
David Simpson
Researcher at North Shore Hospital
Publications - 39
Citations - 2253
David Simpson is an academic researcher from North Shore Hospital. The author has contributed to research in topics: Quantum cosmology & Quantum algorithm. The author has an hindex of 18, co-authored 39 publications receiving 1863 citations. Previous affiliations of David Simpson include Pacific Northwest National Laboratory & Pennsylvania State University.
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Journal ArticleDOI
International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease
David C. Fajgenbaum,Thomas S. Uldrick,Adam Bagg,Dale Frank,David Wu,Gordan Srkalovic,David Simpson,Amy Y. Liu,David M. Menke,Shanmuganathan Chandrakasan,Mary Jo Lechowicz,Raymond S.M. Wong,Sheila K Pierson,Michele Paessler,Jean François Rossi,Makoto Ide,Jason R. Ruth,Michael P. Croglio,Alexander Suarez,Vera P. Krymskaya,Amy Chadburn,Gisele W. B. Colleoni,Sunita D. Nasta,Raj Jayanthan,Christopher S. Nabel,Corey Casper,Angela Dispenzieri,Alexander Fosså,Dermot Kelleher,Razelle Kurzrock,Peter M. Voorhees,Ahmet Dogan,Kazuyuki Yoshizaki,Frits van Rhee,Eric Oksenhendler,Elaine S. Jaffe,Kojo S.J. Elenitoba-Johnson,Megan S. Lim +37 more
TL;DR: The proposed consensus criteria will facilitate consistent diagnosis, appropriate treatment, and collaborative research and exclude infectious, malignant, and autoimmune disorders that can mimic iMCD.
Journal ArticleDOI
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration
Graham M. Strub,M. Paillard,Jie Liang,Ludovic Gomez,Jeremy C. Allegood,Nitai C. Hait,Michael Maceyka,Megan M. Price,Qun Chen,David Simpson,Tomasz Kordula,Sheldon Milstien,Edward J. Lesnefsky,Sarah Spiegel +13 more
TL;DR: It is demonstrated that S1P, produced in the mitochondria mainly by sphin‐gosine kinase 2 (SphK2), binds with high affinity and specificity to prohibitin 2 (PHB2), a highly conserved protein that regulates mitochondrial assembly and function.
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Siltuximab for multicentric Castleman's disease: A randomised, double-blind, placebo-controlled trial
Frits van Rhee,Raymond S.M. Wong,Nikhil C. Munshi,Jean-François Rossi,Xiaoyan Ke,Alexander Fosså,David Simpson,Marcelo Capra,Ting Liu,Ruey Kuen Hsieh,Yeow Tee Goh,Jun Zhu,Seok-Goo Cho,Hanyun Ren,James Cavet,Rajesh Bandekar,Margaret Rothman,Thomas A. Puchalski,Manjula Reddy,Helgi van de Velde,Jessica Vermeulen,Corey Casper +21 more
TL;DR: Siltuximab plus best supportive care was superior tobest supportive care alone for patients with symptomatic multicentric Castleman's disease and well tolerated with prolonged exposure.
Journal ArticleDOI
Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial
Jeffrey H. Lipton,Charles Chuah,Agnès Guerci-Bresler,Gianantonio Rosti,David Simpson,Sarit Assouline,Gabriel Etienne,Franck E. Nicolini,Philipp le Coutre,Richard E. Clark,Leif Stenke,David Andorsky,Vivian G. Oehler,Stephanie Lustgarten,Victor M. Rivera,Timothy P. Clackson,Frank G. Haluska,Michele Baccarani,Jorge E. Cortes,François Guilhot,Andreas Hochhaus,Timothy P. Hughes,Hagop M. Kantarjian,Neil P. Shah,Moshe Talpaz,Michael W. Deininger +25 more
TL;DR: The trial was terminated early, following concerns about vascular adverse events observed in patients given ponatinib in other trials, and the proportion of patients achieving a major molecular response at 12 months did not differ significantly between the two groups.
Journal ArticleDOI
International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease
Frits van Rhee,Peter M. Voorhees,Angela Dispenzieri,Alexander Fosså,Gordan Srkalovic,Makoto Ide,Nikhil C. Munshi,Stephen Schey,Matthew Streetly,Sheila K Pierson,Helen L. Partridge,Sudipto Mukherjee,Dustin Shilling,Katie L. Stone,Amy D Greenway,Jason R. Ruth,Mary Jo Lechowicz,Shanmuganathan Chandrakasan,Raj Jayanthan,Elaine S. Jaffe,Heather A. Leitch,Naveen Pemmaraju,Amy Chadburn,Megan S. Lim,Kojo S.J. Elenitoba-Johnson,Vera P. Krymskaya,Aaron M. Goodman,Christian Hoffmann,Pier Luigi Zinzani,Simone Ferrero,Louis Terriou,Yasuharu Sato,David Simpson,Raymond S.M. Wong,Jean François Rossi,Sunita D. Nasta,Kazuyuki Yoshizaki,Razelle Kurzrock,Thomas S. Uldrick,Corey Casper,Eric Oksenhendler,David C. Fajgenbaum +41 more
TL;DR: These guidelines should help treating physicians to stratify patients based on disease severity in order to select the best available therapeutic option to improve outcomes.