M
Michele Paessler
Researcher at Children's Hospital of Philadelphia
Publications - 65
Citations - 3275
Michele Paessler is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Hemophagocytic lymphohistiocytosis & Medicine. The author has an hindex of 21, co-authored 60 publications receiving 2541 citations. Previous affiliations of Michele Paessler include University of Pennsylvania.
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Journal ArticleDOI
Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).
Michal Marzec,Qian Zhang,Ami Goradia,P.N. Raghunath,Xiaobin Liu,Michele Paessler,Hong Yi Wang,Maria Wysocka,Mangeng Cheng,Bruce A. Ruggeri,Mariusz A. Wasik +10 more
TL;DR: It is reported that the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells strongly express the immunosuppressive cell-surface protein CD274 (PD-L1, B7-H1), as determined on the mRNA and protein level.
Journal Article
Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis.
TL;DR: Occult MAS appears to be common in patients with SJIA who undergo BMA, which suggests that macrophage activation may be integral to the pathogenesis of SJIA, with implications for treatment.
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International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease
David C. Fajgenbaum,Thomas S. Uldrick,Adam Bagg,Dale Frank,David Wu,Gordan Srkalovic,David Simpson,Amy Y. Liu,David M. Menke,Shanmuganathan Chandrakasan,Mary Jo Lechowicz,Raymond S.M. Wong,Sheila K Pierson,Michele Paessler,Jean François Rossi,Makoto Ide,Jason R. Ruth,Michael P. Croglio,Alexander Suarez,Vera P. Krymskaya,Amy Chadburn,Gisele W. B. Colleoni,Sunita D. Nasta,Raj Jayanthan,Christopher S. Nabel,Corey Casper,Angela Dispenzieri,Alexander Fosså,Dermot Kelleher,Razelle Kurzrock,Peter M. Voorhees,Ahmet Dogan,Kazuyuki Yoshizaki,Frits van Rhee,Eric Oksenhendler,Elaine S. Jaffe,Kojo S.J. Elenitoba-Johnson,Megan S. Lim +37 more
TL;DR: The proposed consensus criteria will facilitate consistent diagnosis, appropriate treatment, and collaborative research and exclude infectious, malignant, and autoimmune disorders that can mimic iMCD.
Journal ArticleDOI
Repeated TLR9 stimulation results in macrophage activation syndrome–like disease in mice
Edward M. Behrens,Scott W. Canna,Katharine Slade,Sheila Rao,Portia A. Kreiger,Michele Paessler,Taku Kambayashi,Gary A. Koretzky +7 more
TL;DR: It is shown that repeated stimulation of TLR9 produced an HLH/MAS-like syndrome on a normal genetic background, without exogenous antigen, and that IL-10 played a protective role in this model and that blocking IL- 10 signaling led to the development of hemophagocytosis.
Journal ArticleDOI
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2.
Caroline Diorio,Sarah E. Henrickson,Laura A. Vella,Kevin O McNerney,Julie Chase,Chakkapong Burudpakdee,Jessica H. Lee,Cristina Jasen,Fran Balamuth,David M. Barrett,Brenda Banwell,Kathrin M. Bernt,Allison M. Blatz,Kathleen Chiotos,Brian T. Fisher,Julie C. Fitzgerald,Jeffrey S. Gerber,Kandace Gollomp,Christopher Gray,Stephan A. Grupp,Rebecca M. Harris,Todd J. Kilbaugh,Audrey R. Odom John,Michele P. Lambert,Emily J. Liebling,Michele Paessler,Whitney Petrosa,Charles A. Phillips,Anne F. Reilly,Neil Romberg,Alix E. Seif,Deborah A. Sesok-Pizzini,Kathleen E. Sullivan,Julie Vardaro,Edward M. Behrens,David T. Teachey,Hamid Bassiri +36 more
TL;DR: Pediatric patients with SARS-CoV-2 are at risk for critical illness with severe COVID-19 and MIS-C, a severe and novel pediatric disorder termed Multisystem Inflammatory Syndrome in Children (MIS-C).