D
Daniel J. Carucci
Researcher at Naval Medical Research Center
Publications - 79
Citations - 13294
Daniel J. Carucci is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 40, co-authored 79 publications receiving 12773 citations. Previous affiliations of Daniel J. Carucci include Government of the United States of America & Foundation for the National Institutes of Health.
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Journal ArticleDOI
Early Gamma Interferon and Interleukin-2 Responses to Vaccination Predict the Late Resting Memory in Malaria-Naive and Malaria-Exposed Individuals
Philip Bejon,Philip Bejon,Sheila M. Keating,Jedidah Mwacharo,Oscar Kai,Susanna Dunachie,Michael Walther,Tamara Berthoud,Trudie Lang,J. E. Epstein,Daniel J. Carucci,Philippe Moris,Joe Cohen,Sarah C. Gilbert,Norbert Peshu,Kevin Marsh,Kevin Marsh,Adrian V. S. Hill,Adrian V. S. Hill +18 more
TL;DR: It is demonstrated that double-cytokine-producing cells were highly predictive of memory in malaria-exposed volunteers and may be useful in predicting vaccinations most likely to generate stable, long-term memory responses.
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Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines.
Gary T. Brice,Carlota Dobaño,Carlota Dobaño,Martha Sedegah,Maureen E. Stefaniak,Norma L. Graber,Joseph J. Campo,Daniel J. Carucci,Denise L. Doolan,Denise L. Doolan,Denise L. Doolan +10 more
TL;DR: It is found that increasing the interval between immunizations significantly enhanced the frequency and magnitude of CD8+ and CD4+ T cell responses as well as protective immunity against sporozoite challenge and was more important than the total number of immunizations.
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Vaxfectin™ enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccines
Martha Sedegah,William O. Rogers,Arnel Belmonte,Maria Belmonte,Glenna Banania,Noelle B. Patterson,Marilyn Ferrari,David C. Kaslow,Daniel J. Carucci,Thomas L. Richie,Denise L. Doolan +10 more
TL;DR: The capacity of the cationic lipid based formulation, Vaxfectin, to enhance the immunogenicity and protective efficacy of DNA-based vaccine regimens in the Plasmodium yoelii murine malaria model is evaluated.
Journal ArticleDOI
Molecular approaches to malaria
Klaus Lingelbach,Kiaran Kirk,Stephen J. Rogerson,Jean Langhorne,Daniel J. Carucci,Andrew P. Waters +5 more
TL;DR: The results and new research avenues presented at a recent meeting held with the aim of developing interdisciplinary approaches to combat this disease are summarized.
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A glycosylphosphatidylinositol anchor signal sequence enhances the immunogenicity of a DNA vaccine encoding Plasmodium falciparum sexual-stage antigen, Pfs230.
Sarah L. Fanning,Beata Czesny,Martha Sedegah,Martha Sedegah,Daniel J. Carucci,Geert-Jan van Gemert,Wijnand Eling,Kim C. Williamson +7 more
TL;DR: Mammalian expression vectors encoding region C of malaria transmission-blocking vaccine candidate Pfs230 with and without a 3' glycosylphosphatidylinositol (GPI) anchor signal sequence were tested for their immunogenicity in mice and none of these vaccination strategies were more effective than r230/MBP.C alone.