Daniel Wenzel

TL;DR: A human pluripotent stem cell-derived three-dimensional organoid culture system that develops various discrete, although interdependent, brain regions that include a cerebral cortex containing progenitor populations that organize and produce mature cortical neuron subtypes is developed.

TL;DR: The findings reveal the histone chaperone CAF-1 to be a novel regulator of somatic cell identity during transcription-factor-induced cell-fate transitions and provide a potential strategy to modulate cellular plasticity in a regenerative setting.

TL;DR: It is shown that cluster size varies dynamically during development and can be substantially larger than previously thought, with the Igf2r cluster extending over 10 Mb in placenta, and escape from X-inactivation is tissue-specific, with leg muscle showing an unexpectedly high rate of XCI escapers.

TL;DR: A novel quantitative approach to identify intact glycopeptides from comparative proteomic data sets, allowing us not only to infer complex glycan structures but also to directly map them to sites within the associated proteins at the proteome scale.

TL;DR: iPSCs derived from fibroblasts with mutant type VII collagen were genetically corrected and used as cell therapy in mice with recessive dystrophic epidermolysis bullosa, suggesting that RDEB skin could be effectively and safely repaired using iPSC-based cell therapy.