Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes
Jessica Quintin,Sadia Saeed,Joost H.A. Martens,Evangelos J. Giamarellos-Bourboulis,Daniela C. Ifrim,Colin Logie,Liesbeth Jacobs,Trees Jansen,Bart Jan Kullberg,Cisca Wijmenga,Leo A. B. Joosten,Ramnik J. Xavier,Jos W. M. van der Meer,Hendrik G. Stunnenberg,Mihai G. Netea +14 more
TLDR
The functional reprogramming of monocytes, reminiscent of similar NK cell properties, supports the concept of "trained immunity" and may be employed for the design of improved vaccination strategies.About:
This article is published in Cell Host & Microbe.The article was published on 2012-08-16 and is currently open access. It has received 876 citations till now. The article focuses on the topics: Immune system & Candida albicans.read more
Citations
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Trained immunity: A program of innate immune memory in health and disease
Mihai G. Netea,Leo A. B. Joosten,Eicke Latz,Kingston H. G. Mills,Gioacchino Natoli,Hendrik G. Stunnenberg,Luke A. J. O'Neill,Ramnik J. Xavier +7 more
TL;DR: Proof-of-principle experimental studies support the hypothesis that trained immunity is one of the main immunological processes that mediate the nonspecific protective effects against infections induced by vaccines, such as bacillus Calmette-Guérin or measles vaccination.
Journal ArticleDOI
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Paola Italiani,Diana Boraschi +1 more
TL;DR: This review will address some of the important questions under the general framework of the role of monocytes and macrophages in the initiation, development, resolution, and chronicization of inflammation.
Journal ArticleDOI
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Shih-Chin Cheng,Jessica Quintin,Robert A. Cramer,Kelly M. Shepardson,Sadia Saeed,Vinod Kumar,Evangelos J. Giamarellos-Bourboulis,Joost H.A. Martens,Nagesha Appukudige Rao,Ali Aghajanirefah,Ganesh R. Manjeri,Yang Li,Daniela C. Ifrim,Rob J.W. Arts,Brian M. J. W. van der Veer,Peter M.T. Deen,Colin Logie,Luke A. J. O'Neill,Peter H.G.M. Willems,Frank L. van de Veerdonk,Jos W. M. van der Meer,Aylwin Ng,Aylwin Ng,Leo A. B. Joosten,Cisca Wijmenga,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea +28 more
TL;DR: The identification of glycolysis as a fundamental process in trained immunity further highlights a key regulatory role for metabolism in innate host defense and defines a potential therapeutic target in both infectious and inflammatory diseases.
Journal ArticleDOI
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Sadia Saeed,Jessica Quintin,Hindrik H. D. Kerstens,Nagesha A.S. Rao,Ali Aghajanirefah,Filomena Matarese,Shih-Chin Cheng,Jacqueline M. Ratter,Kim Berentsen,Martijn van der Ent,Nilofar Sharifi,Eva M. Janssen-Megens,Menno ter Huurne,Amit Mandoli,Tom van Schaik,Aylwin Ng,Aylwin Ng,Frances Burden,Kate Downes,Mattia Frontini,Vinod Kumar,Evangelos J. Giamarellos-Bourboulis,Willem H. Ouwehand,Jos W. M. van der Meer,Leo A. B. Joosten,Cisca Wijmenga,Joost H.A. Martens,Ramnik J. Xavier,Ramnik J. Xavier,Colin Logie,Mihai G. Netea,Hendrik G. Stunnenberg +31 more
TL;DR: The epigenetic and transcriptional programs of monocyte differentiation to macrophages that distinguish tolerant and trained macrophage phenotypes are uncovered, providing a resource to further understand and manipulate immune-mediated responses.
Journal ArticleDOI
Defining trained immunity and its role in health and disease
Mihai G. Netea,Mihai G. Netea,Jorge Domínguez-Andrés,Luis B. Barreiro,Luis B. Barreiro,Triantafyllos Chavakis,Triantafyllos Chavakis,Maziar Divangahi,Maziar Divangahi,Elaine Fuchs,Leo A. B. Joosten,Jos W. M. van der Meer,Musa M. Mhlanga,Musa M. Mhlanga,Willem J. M. Mulder,Willem J. M. Mulder,Niels P. Riksen,Andreas Schlitzer,Joachim L. Schultze,Christine Stabell Benn,Joseph C. Sun,Joseph C. Sun,Ramnik J. Xavier,Ramnik J. Xavier,Eicke Latz,Eicke Latz,Eicke Latz +26 more
TL;DR: A group of leaders in the field define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
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Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
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