D
Daniela Parolaro
Researcher at University of Insubria
Publications - 110
Citations - 8329
Daniela Parolaro is an academic researcher from University of Insubria. The author has contributed to research in topics: Cannabinoid receptor & Cannabinoid. The author has an hindex of 53, co-authored 110 publications receiving 7467 citations.
Papers
More filters
Journal ArticleDOI
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Nitin Agarwal,Pal Pacher,Irmgard Tegeder,Fumimasa Amaya,Cristina E. Constantin,Gary J. Brenner,Tiziana Rubino,Christoph W. Michalski,Giovanni Marsicano,Krisztina Monory,Ken Mackie,Claudiu Marian,Sandor Batkai,Daniela Parolaro,Michael Fischer,Peter W. Reeh,George Kunos,Michaela Kress,Beat Lutz,Clifford J. Woolf,Rohini Kuner +20 more
TL;DR: It is concluded that the contribution of CB1-type receptors expressed on the peripheral terminals of nociceptors to cannabinoid-induced analgesia is paramount, which should enable the development of peripherally acting CB1 analgesic agonists without any central side effects.
Journal ArticleDOI
Pharmacologic Rescue of Impaired Cognitive Flexibility, Social Deficits, Increased Aggression, and Seizure Susceptibility in Oxytocin Receptor Null Mice: A Neurobehavioral Model of Autism
Mariaelvina Sala,Daniela Braida,Daniela Lentini,Marta Busnelli,Elisabetta Bulgheroni,Valeria Capurro,Annamaria Finardi,Andrea Donzelli,Linda Pattini,Tiziana Rubino,Daniela Parolaro,Katsuhiko Nishimori,Marco Parenti,Bice Chini +13 more
TL;DR: It is shown that autistic-like symptoms are rescued on administration of AVP and OT to young Oxtr(-/-) adult animals and that intracerebral administration of both OT and AVP lowers aggression and fully reverts social and learning defects by acting on V1a receptors and that seizure susceptibility is antagonized by peripherally administered OT.
Journal ArticleDOI
Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
TL;DR: The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.
Journal ArticleDOI
Role in Anxiety Behavior of the Endocannabinoid System in the Prefrontal Cortex
Tiziana Rubino,Natalia Realini,Chiara Castiglioni,C. Guidali,Daniela Viganò,Emanuela Marras,Stefania Petrosino,Gianpaolo Perletti,Mauro Maccarrone,V. Di Marzo,Daniela Parolaro +10 more
TL;DR: Findings support an anxiolytic role for physiological increases in AEA in the PFC, whereas more marked increases or decreases of this endocannabinoid might lead to an anxiogenic response due to TRPV1 stimulation or the lack of CB1 activation, respectively.
Journal ArticleDOI
Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood.
Tiziana Rubino,Natalia Realini,Daniela Braida,Sandra Guidi,Valeria Capurro,Daniela Viganò,C. Guidali,Marta Pinter,Mariaelvina Sala,Renata Bartesaghi,Daniela Parolaro +10 more
TL;DR: The data suggest that THC pretreated rats may establish less synaptic contacts and/or less efficient synaptic connections throughout the hippocampus and this could represent the molecular underpinning of the cognitive deficit induced by adolescent THC treatment.