Journal ArticleDOI
Pharmacologic Rescue of Impaired Cognitive Flexibility, Social Deficits, Increased Aggression, and Seizure Susceptibility in Oxytocin Receptor Null Mice: A Neurobehavioral Model of Autism
Mariaelvina Sala,Daniela Braida,Daniela Lentini,Marta Busnelli,Elisabetta Bulgheroni,Valeria Capurro,Annamaria Finardi,Andrea Donzelli,Linda Pattini,Tiziana Rubino,Daniela Parolaro,Katsuhiko Nishimori,Marco Parenti,Bice Chini +13 more
TLDR
It is shown that autistic-like symptoms are rescued on administration of AVP and OT to young Oxtr(-/-) adult animals and that intracerebral administration of both OT and AVP lowers aggression and fully reverts social and learning defects by acting on V1a receptors and that seizure susceptibility is antagonized by peripherally administered OT.About:
This article is published in Biological Psychiatry.The article was published on 2011-05-01. It has received 338 citations till now. The article focuses on the topics: Oxytocin receptor.read more
Citations
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Journal ArticleDOI
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Inga D. Neumann,Rainer Landgraf +1 more
TL;DR: Shifting the balance between the neuropeptide systems towards oxytocin, by positive social stimuli and/or psychopharmacotherapy, may help to improve emotional behaviors and reinstate mental health.
Journal ArticleDOI
Advancing the understanding of autism disease mechanisms through genetics
TL;DR: Current understanding of the genetic architecture of ASD is reviewed and genetic evidence, neuropathology and studies in model systems with how they inform mechanistic models of ASD pathophysiology are integrated.
Journal ArticleDOI
The Oxytocin Receptor: From Intracellular Signaling to Behavior
Benjamin Jurek,Inga D. Neumann +1 more
TL;DR: The mechanisms of OXT expression and release, expression and binding of the OXTR in brain and periphery, OX TR-coupled signaling cascades, and their involvement in behavioral outcomes are discussed to assemble a comprehensive picture of the central and peripheral OXT system.
Journal ArticleDOI
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Maurice Manning,Aleksandra Misicka,Aleksandra Misicka,Aleksandra Olma,Aleksandra Olma,K. Bankowski,Stoytcho Stoev,Bice Chini,Thierry Durroux,Bernard Mouillac,Maithé Corbani,Gilles Guillon +11 more
TL;DR: The status of peptide and non-peptide agonists and antagonists for the V1a, V1b and V2 receptors for arginine vasopressin (AVP) and the O2 receptor for oxytocin (OT) was reviewed in this paper.
Journal ArticleDOI
Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders.
Eunee Lee,Jiseok Lee,Eunjoon Kim +2 more
TL;DR: The results suggest that excitation and inhibition imbalances may contribute to the development and maintenance of autism spectrum disorders and represent an important therapeutic target.
References
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Journal ArticleDOI
Book reviewHandbook of Chemical Neuroanatomy: Methods in Chemical Neuroanatomy. Edited by A. Bjorklund and T. Hokfelt. Elsevier, Amsterdam, 1983. Cloth bound, 548 pp. UK £140. (Volume 1 in the series).
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The establishment of polarity by hippocampal neurons in culture
TL;DR: By the end of the first week in culture, hippocampal neurons have established a single axon and several dendrites, which is a stereotyped sequence of developmental events that lead to the establishment of this characteristic form.
Journal ArticleDOI
Culturing hippocampal neurons
Stefanie Kaech,Gary Banker +1 more
TL;DR: This protocol provides protocols for preparing low-density dissociated-cell cultures of hippocampal neurons from embryonic rats or mice that become appropriately polarized, develop extensive axonal and dendritic arbors and form numerous, functional synaptic connections with one another.
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Oxytocin, vasopressin, and the neurogenetics of sociality.
Zoe R. Donaldson,Larry J. Young +1 more
TL;DR: There is growing evidence that the neuropeptides oxytocin and vasopressin modulate complex social behavior and social cognition and suggest that variation in the genes encoding their receptors may contribute to variation in human social behavior by altering brain function.
Journal ArticleDOI
Autism spectrum disorders: developmental disconnection syndromes.
Daniel H. Geschwind,Pat Levitt +1 more
TL;DR: A potential unifying model in which higher-order association areas of the brain that normally connect to the frontal lobe are partially disconnected during development can accommodate the specific neurobehavioral features observed in autism, their emergence during development, and the heterogeneity of autism etiology, behaviors and cognition.
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