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Danielle Fink
Researcher at Leidos
Publications - 20
Citations - 1379
Danielle Fink is an academic researcher from Leidos. The author has contributed to research in topics: Medicine & Inflammation. The author has an hindex of 9, co-authored 14 publications receiving 820 citations. Previous affiliations of Danielle Fink include Science Applications International Corporation.
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Journal ArticleDOI
Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia
Donald C. Vinh,Smita Y. Patel,Gulbu Uzel,Victoria L. Anderson,Alexandra F. Freeman,Alexandra F. Freeman,Kenneth N. Olivier,Christine Spalding,Stephen M. Hughes,Stefania Pittaluga,Mark Raffeld,Lynn Sorbara,Houda Elloumi,Douglas B. Kuhns,Maria L. Turner,Edward W. Cowen,Danielle Fink,Debra Long-Priel,Amy P. Hsu,Li Ding,Michelle L. Paulson,Adeline R. Whitney,Elizabeth P. Sampaio,David M. Frucht,Frank R. DeLeo,Steven M. Holland +25 more
TL;DR: This novel clinical syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern.
Journal ArticleDOI
An immune-based biomarker signature is associated with mortality in COVID-19 patients.
Michael S. Abers,Ottavia M. Delmonte,Emily Ricotta,Jonathan Fintzi,Danielle Fink,Adriana Almeida de Jesus,Kol A. Zarember,Sara Alehashemi,Vasileios Oikonomou,Jigar V. Desai,Scott W. Canna,Bita Shakoory,Kerry Dobbs,Luisa Imberti,Alessandra Sottini,Eugenia Quiros-Roldan,Francesco Castelli,Camillo Rossi,Duilio Brugnoni,Andrea Biondi,Laura Rachele Bettini,Mariella D'Angiò,Paolo Bonfanti,Riccardo Castagnoli,Daniela Montagna,Amelia Licari,Gian Luigi Marseglia,Emily F. Gliniewicz,Elana Shaw,Dana Kahle,Andre Rastegar,Michael Stack,Katherine Myint-Hpu,Susan L Levinson,Mark J. DiNubile,Daniel W. Chertow,Peter D. Burbelo,Jeffrey I. Cohen,Katherine R. Calvo,John S. Tsang,Helen C. Su,John I. Gallin,Douglas B. Kuhns,Raphaela Goldbach-Mansky,Michail S. Lionakis,Luigi D. Notarangelo +45 more
TL;DR: Levels of sST2, sTNFRSF1A, IL-10, and IL-15 were consistently higher throughout the hospitalization in patients who died versus those who recovered, suggesting that these biomarkers may provide an early warning of eventual disease outcome.
Journal ArticleDOI
CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System
Rebecca A. Drummond,Amanda L. Collar,Muthulekha Swamydas,Carlos A. Rodriguez,Jean K. Lim,Laura Mendez,Danielle Fink,Amy P. Hsu,Bing Zhai,Hatice Karauzum,Constantinos M. Mikelis,Stacey R. Rose,Elise M. N. Ferré,Lynne Yockey,Kimberly Lemberg,Hye Sun Kuehn,Sergio D. Rosenzweig,Xin Lin,Prashant Chittiboina,Sandip K. Datta,Thomas H. Belhorn,Eric T. Weimer,Michelle L. Hernandez,Tobias M. Hohl,Douglas B. Kuhns,Michail S. Lionakis +25 more
TL;DR: It is shown that a patient with CARD9 deficiency had impaired neutrophil accumulation and induction of neutrophils-recruiting CXC chemokines in the cerebrospinal fluid despite uncontrolled CNS Candida infection, and this work phenocopied the human susceptibility in Card9 -/- mice, providing novel insight into the CNS fungal susceptibility of CARD9-deficient humans.
Journal ArticleDOI
Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19.
Can Liu,Can Liu,Andrew J. Martins,William W. Lau,Nicholas Rachmaninoff,Nicholas Rachmaninoff,Jinguo Chen,Luisa Imberti,Darius Mostaghimi,Danielle Fink,Peter D. Burbelo,Kerry Dobbs,Ottavia M. Delmonte,Neha Bansal,Laura Failla,Alessandra Sottini,Eugenia Quiros-Roldan,Kyu Lee Han,Brian Sellers,Foo Cheung,Rachel Sparks,Tae Wook Chun,Susan Moir,Michail S. Lionakis,Michael S. Abers,Richard Apps,Marita Bosticardo,Pedro Milanez-Almeida,Matthew P. Mulé,Elana Shaw,Yu Zhang,Francesco Castelli,Maria Lorenza Muiesan,Gabriele Tomasoni,Francesco Scolari,Alessandra Tucci,Camillo Rossi,Helen C. Su,Douglas B. Kuhns,Jeffrey I. Cohen,Luigi D. Notarangelo,John S. Tsang +41 more
TL;DR: In this article, the authors longitudinally assessed circulating proteins as well as 188 surface protein markers, transcriptome, and T-cell receptor sequence simultaneously in single peripheral immune cells from COVID-19 patients.
Journal ArticleDOI
X-linked carriers of chronic granulomatous disease: Illness, lyonization, and stability.
Beatriz E. Marciano,Christa S. Zerbe,E. Liana Falcone,Li Ding,Suk See DeRavin,Janine Daub,Samantha Kreuzburg,Lynne Yockey,Sally Hunsberger,Ladan Foruraghi,Lisa A. Barnhart,Kabir Matharu,Victoria L. Anderson,Dirk Darnell,Cathleen Frein,Danielle Fink,Karen P. Lau,Debra A. Long Priel,John I. Gallin,Harry L. Malech,Gulbu Uzel,Alexandra F. Freeman,Douglas B. Kuhns,Sergio D. Rosenzweig,Steven M. Holland +24 more
TL;DR: A low %DHR+ value strongly predicts infection risk in X‐linked CGD carriers, and the carrier state itself is associated with autoimmunity.