M
Mariella D'Angiò
Researcher at University of Milano-Bicocca
Publications - 18
Citations - 5600
Mariella D'Angiò is an academic researcher from University of Milano-Bicocca. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 7, co-authored 12 publications receiving 3066 citations. Previous affiliations of Mariella D'Angiò include University of Kiel.
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Journal ArticleDOI
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Paul Bastard,Paul Bastard,Paul Bastard,Lindsey B. Rosen,Qian Zhang,Eleftherios Michailidis,Hans-Heinrich Hoffmann,Yu Zhang,Karim Dorgham,Quentin Philippot,Quentin Philippot,Jérémie Rosain,Jérémie Rosain,Vivien Béziat,Vivien Béziat,Vivien Béziat,Jeremy Manry,Jeremy Manry,Elana Shaw,Liis Haljasmägi,Pärt Peterson,Lazaro Lorenzo,Lazaro Lorenzo,Lucy Bizien,Lucy Bizien,Sophie Trouillet-Assant,Kerry Dobbs,Adriana Almeida de Jesus,Alexandre Belot,Anne Kallaste,Emilie Catherinot,Yacine Tandjaoui-Lambiotte,Jérémie Le Pen,Gaspard Kerner,Gaspard Kerner,Benedetta Bigio,Yoann Seeleuthner,Yoann Seeleuthner,Rui Yang,Alexandre Bolze,András N Spaan,András N Spaan,Ottavia M. Delmonte,Michael S. Abers,Alessandro Aiuti,Giorgio Casari,Vito Lampasona,Lorenzo Piemonti,Fabio Ciceri,Kaya Bilguvar,Richard P. Lifton,Richard P. Lifton,Marc Vasse,David M. Smadja,Mélanie Migaud,Mélanie Migaud,Jérôme Hadjadj,Benjamin Terrier,Darragh Duffy,Lluis Quintana-Murci,Lluis Quintana-Murci,Diederik van de Beek,Lucie Roussel,Donald C. Vinh,Stuart G. Tangye,Stuart G. Tangye,Filomeen Haerynck,David Dalmau,Javier Martinez-Picado,Javier Martinez-Picado,Petter Brodin,Petter Brodin,Michel C. Nussenzweig,Michel C. Nussenzweig,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Carlos Rodríguez-Gallego,Guillaume Vogt,Trine H. Mogensen,Trine H. Mogensen,Andrew J. Oler,Jingwen Gu,Peter D. Burbelo,Jeffrey I. Cohen,Andrea Biondi,Laura Rachele Bettini,Mariella D'Angiò,Paolo Bonfanti,Patrick Rossignol,Julien Mayaux,Frédéric Rieux-Laucat,Eystein S. Husebye,Eystein S. Husebye,Eystein S. Husebye,Francesca Fusco,Matilde Valeria Ursini,Luisa Imberti,Alessandra Sottini,Simone Paghera,Eugenia Quiros-Roldan,Camillo Rossi,Riccardo Castagnoli,Daniela Montagna,Amelia Licari,Gian Luigi Marseglia,Xavier Duval,Jade Ghosn,Hgid Lab,Covid Clinicians,Covid-Storm Clinicians§,CoV-Contact Cohort§,Amsterdam Umc Covid Biobank,Amsterdam Umc Covid Biobank,Amsterdam Umc Covid Biobank,Covid Human Genetic Effort,John S. Tsang,Raphaela Goldbach-Mansky,Kai Kisand,Michail S. Lionakis,Anne Puel,Anne Puel,Anne Puel,Shen-Ying Zhang,Shen-Ying Zhang,Shen-Ying Zhang,Steven M. Holland,Guy Gorochov,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Charles M. Rice,Aurélie Cobat,Aurélie Cobat,Aurélie Cobat,Luigi D. Notarangelo,Laurent Abel,Laurent Abel,Laurent Abel,Helen C. Su,Jean-Laurent Casanova +140 more
TL;DR: A means by which individuals at highest risk of life-threatening COVID-19 can be identified is identified, and the hypothesis that neutralizing auto-Abs against type I IFNs may underlie critical CO VID-19 is tested.
Journal ArticleDOI
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Qian Zhang,Paul Bastard,Paul Bastard,Zhiyong Liu,Jérémie Le Pen,Marcela Moncada-Vélez,Jie Chen,Masato Ogishi,Ira K. D. Sabli,Stephanie Hodeib,Cecilia B. Korol,Jérémie Rosain,Jérémie Rosain,Kaya Bilguvar,Junqiang Ye,Alexandre Bolze,Benedetta Bigio,Rui Yang,Andrés Augusto Arias,Andrés Augusto Arias,Qinhua Zhou,Yu Zhang,Fanny Onodi,Sarantis Korniotis,Léa Karpf,Quentin Philippot,Quentin Philippot,Marwa Chbihi,Marwa Chbihi,Lucie Bonnet-Madin,Karim Dorgham,Nikaïa Smith,William M. Schneider,Brandon S. Razooky,Hans-Heinrich Hoffmann,Eleftherios Michailidis,Leen Moens,Ji Eun Han,Lazaro Lorenzo,Lazaro Lorenzo,Lucy Bizien,Lucy Bizien,Philip Meade,Anna-Lena Neehus,Anna-Lena Neehus,Aileen Camille Ugurbil,Aurélien Corneau,Gaspard Kerner,Gaspard Kerner,Peng Zhang,Franck Rapaport,Yoann Seeleuthner,Yoann Seeleuthner,Jeremy Manry,Jeremy Manry,Cécile Masson,Yohann Schmitt,Agatha Schlüter,Tom Le Voyer,Tom Le Voyer,Taushif Khan,Juan Li,Jacques Fellay,Jacques Fellay,Lucie Roussel,Mohammad Shahrooei,Mohammed F. Alosaimi,Davood Mansouri,Haya Al-Saud,Fahd Al-Mulla,Feras M. Almourfi,Saleh Al-Muhsen,Fahad Alsohime,Saeed Al Turki,Rana Hasanato,Diederik van de Beek,Andrea Biondi,Laura Rachele Bettini,Mariella D'Angiò,Paolo Bonfanti,Luisa Imberti,Alessandra Sottini,Simone Paghera,Eugenia Quiros-Roldan,Camillo Rossi,Andrew J. Oler,Miranda F. Tompkins,Camille Alba,Isabelle Vandernoot,Jean-Christophe Goffard,Guillaume Smits,Isabelle Migeotte,Filomeen Haerynck,Pere Soler-Palacín,Andrea Martín-Nalda,Roger Colobran,Pierre-Emmanuel Morange,Sevgi Keles,Fatma Çölkesen,Tayfun Ozcelik,Kadriye Kart Yaşar,Sevtap Şenoğlu,Şemsi Nur Karabela,Carlos Rodríguez-Gallego,Giuseppe Novelli,Sami Hraiech,Yacine Tandjaoui-Lambiotte,Xavier Duval,Xavier Duval,Cédric Laouénan,Cédric Laouénan,Covid-Storm Clinicians§,Covid Clinicians,CoV-Contact Cohort§,CoV-Contact Cohort§,Amsterdam Umc Covid Biobank,Covid Human Genetic Effort,Niaid-Usuhs,Niaid-Usuhs,Niaid-Usuhs,Andrew L. Snow,Clifton L. Dalgard,Joshua D. Milner,Donald C. Vinh,Donald C. Vinh,Trine H. Mogensen,Trine H. Mogensen,Nico Marr,András N Spaan,András N Spaan,András N Spaan,Bertrand Boisson,Bertrand Boisson,Bertrand Boisson,Stéphanie Boisson-Dupuis,Jacinta Bustamante,Jacinta Bustamante,Jacinta Bustamante,Anne Puel,Michael J. Ciancanelli,Isabelle Meyts,Tom Maniatis,Vassili Soumelis,Ali Amara,Ali Amara,Michel C. Nussenzweig,Adolfo García-Sastre,Florian Krammer,Aurora Pujol,Darragh Duffy,Darragh Duffy,Richard P. Lifton,Richard P. Lifton,Richard P. Lifton,Shen-Ying Zhang,Guy Gorochov,Guy Gorochov,Guy Gorochov,Vivien Béziat,Vivien Béziat,Vivien Béziat,Emmanuelle Jouanguy,Vanessa Sancho-Shimizu,Charles M. Rice,Charles M. Rice,Charles M. Rice,Laurent Abel,Luigi D. Notarangelo,Luigi D. Notarangelo,Luigi D. Notarangelo,Aurélie Cobat,Helen C. Su,Jean-Laurent Casanova +172 more
TL;DR: The COVID Human Genetic Effort established to test the general hypothesis that life-threatening COVID-19 in some or most patients may be caused by monogenic inborn errors of immunity to SARS-CoV-2 with incomplete or complete penetrance finds an enrichment in variants predicted to be loss-of-function (pLOF), with a minor allele frequency <0.001.
Journal ArticleDOI
Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
David Ellinghaus,Frauke Degenhardt,Luis Bujanda,Maria Buti,Agustín Albillos,Pietro Invernizzi,J. Fernández,Daniele Prati,Guido Baselli,Rosanna Asselta,Marit Mæhle Grimsrud,Chiara Milani,Fatima Aziz,Jan Christian Kässens,Sandra May,Mareike Wendorff,Lars Wienbrandt,Florian Uellendahl-Werth,Tenghao Zheng,Xiaoli Yi,Raúl de Pablo,Adolfo Garrido Chercoles,Adriana Palom,Alba Estela Garcia-Fernandez,Francisco Rodriguez-Frias,Alberto Zanella,Alessandra Bandera,Alessandro Protti,Alessio Aghemo,Ana Lleo,Andrea Biondi,Andrea Caballero-Garralda,Andrea Gori,Anja Tanck,Anna Carreras Nolla,Anna Latiano,Anna Ludovica Fracanzani,Anna Peschuck,Antonio Julià,Antonio Pesenti,Antonio Voza,David Jiménez,Beatriz Mateos,Beatriz Nafria Jimenez,Carmen Quereda,Cinzia Paccapelo,Christoph Gassner,Claudio Angelini,Cristina Cea,Aurora Solier,David Pestana,Eduardo Muñiz-Diaz,Elena Sandoval,Elvezia Maria Paraboschi,Enrique Navas,Félix García Sánchez,Ferruccio Ceriotti,F. Martinelli-Boneschi,Flora Peyvandi,Francesco Blasi,Luis Téllez,Albert Blanco-Grau,Georg Hemmrich-Stanisak,Giacomo Grasselli,Giorgio Costantino,Giulia Cardamone,Giuseppe Foti,Serena Aneli,Hayato Kurihara,Hesham ElAbd,Ilaria My,Iván Galván-Femenía,Javier Martin,Jeanette Erdmann,José Ferrusquía-Acosta,Koldo Garcia-Etxebarria,Laura Izquierdo-Sanchez,Laura Rachele Bettini,Lauro Sumoy,Leonardo Terranova,Leticia Moreira,Luigi Santoro,Luigia Scudeller,Francisco Mesonero,Luisa Roade,Malte C. Rühlemann,Marco Schaefer,Maria Carrabba,Mar Riveiro-Barciela,Maria Eloina Figuera Basso,Maria Grazia Valsecchi,María Hernández-Tejero,Marialbert Acosta-Herrera,Mariella D'Angiò,Marina Baldini,Marina Cazzaniga,Martin Schulzky,Maurizio Cecconi,Michael Wittig,Michele Ciccarelli,Miguel Rodríguez-Gandía,Monica Bocciolone,Monica Miozzo,Nicola Montano,Nicole Braun,Nicoletta Sacchi,Nilda Martinez,Onur Özer,Orazio Palmieri,Paola Faverio,Paoletta Preatoni,Paolo Bonfanti,Paolo Omodei,Paolo Tentorio,Pedro Castro,Pedro M. Rodrigues,Aaron Blandino Ortiz,Rafael de Cid,Ricard Ferrer,Roberta Gualtierotti,Rosa Nieto,Siegfried Goerg,Salvatore Badalamenti,Sara Marsal,Giuseppe Matullo,Serena Pelusi,Simonas Juzenas,Stefano Aliberti,Valter Monzani,Victor Moreno,Tanja Wesse,Tobias L. Lenz,Tomás Pumarola,Valeria Rimoldi,Silvano Bosari,Wolfgang Albrecht,Wolfgang Peter,Manuel Romero-Gómez,Mauro D'Amato,Stefano Duga,Jesus M. Banales,Johannes R. Hov,Trine Folseraas,Luca Valenti,Andre Franke,Tom H. Karlsen +145 more
TL;DR: A 3p21.31 gene cluster is identified as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and a potential involvement of the ABO blood-group system is confirmed.
Journal ArticleDOI
An immune-based biomarker signature is associated with mortality in COVID-19 patients.
Michael S. Abers,Ottavia M. Delmonte,Emily Ricotta,Jonathan Fintzi,Danielle Fink,Adriana Almeida de Jesus,Kol A. Zarember,Sara Alehashemi,Vasileios Oikonomou,Jigar V. Desai,Scott W. Canna,Bita Shakoory,Kerry Dobbs,Luisa Imberti,Alessandra Sottini,Eugenia Quiros-Roldan,Francesco Castelli,Camillo Rossi,Duilio Brugnoni,Andrea Biondi,Laura Rachele Bettini,Mariella D'Angiò,Paolo Bonfanti,Riccardo Castagnoli,Daniela Montagna,Amelia Licari,Gian Luigi Marseglia,Emily F. Gliniewicz,Elana Shaw,Dana Kahle,Andre Rastegar,Michael Stack,Katherine Myint-Hpu,Susan L Levinson,Mark J. DiNubile,Daniel W. Chertow,Peter D. Burbelo,Jeffrey I. Cohen,Katherine R. Calvo,John S. Tsang,Helen C. Su,John I. Gallin,Douglas B. Kuhns,Raphaela Goldbach-Mansky,Michail S. Lionakis,Luigi D. Notarangelo +45 more
TL;DR: Levels of sST2, sTNFRSF1A, IL-10, and IL-15 were consistently higher throughout the hospitalization in patients who died versus those who recovered, suggesting that these biomarkers may provide an early warning of eventual disease outcome.
Journal ArticleDOI
Children with cancer in the time of COVID-19: An 8-week report from the six pediatric onco-hematology centers in Lombardia, Italy.
Andrea Ferrari,Marco Zecca,Carmelo Rizzari,Fulvio Porta,Massimo Provenzi,Maddalena Marinoni,Richard Fabian Schumacher,Roberto Luksch,Monica Terenziani,Michela Casanova,Filippo Spreafico,Stefano Chiaravalli,Francesca Compagno,Federica Bruni,Chiara Piccolo,Laura Rachele Bettini,Mariella D'Angiò,Giulia Maria Ferrari,Andrea Biondi,Maura Massimino,Adriana Balduzzi +20 more
TL;DR: The impact of the COVID-19 pandemic onpediatric cancer patients over an 8-week period elapsing from the day of the Italian outbreak to the time of writing (April 15, 2020) in Lombardia region, the epicenter of the pandemic in Italy and one of the worst-hit areas in Europe.