Danilo Cimadomo

TL;DR: This study provides knowledge for a better laboratory and clinical management of blastocyst stage PGS cycles suggesting that the commonly used parameters ofblastocyst evaluation are not good enough indicators to improve the selection among euploid embryos.

TL;DR: The main strategies proposed to improve the management of advanced maternal age women in IVF: fertility preservation through oocyte cryopreservation to prevent aging; optimization of the ovarian stimulation and enhancement of embryo selection to limit its effects; and oocyte donation to circumvent its consequences.

TL;DR: This work generates genome-wide maps of crossovers and chromosome segregation patterns by recovering all three products of single female meioses, and uncovers a new reverse chromosome segregation pattern in which both homologs separate their sister chromatids at meiosis I.

TL;DR: The authors show that chromosome structure erodes only with advancing age, acting as a “molecular clock” for reproductive senescence, and suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.

TL;DR: Stimulation with an identical protocol in the FP and LP of the same menstrual cycle resulted in a similar number of blastocysts in patients with reduced ovarian response, thus increasing the number of patients undergoing transfer per menstrual cycle.