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Andrew Chi-Ho Chan
Researcher at University of Copenhagen
Publications - 6
Citations - 479
Andrew Chi-Ho Chan is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Homologous recombination & Homologous chromosome. The author has an hindex of 4, co-authored 5 publications receiving 275 citations. Previous affiliations of Andrew Chi-Ho Chan include University of Sussex.
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Journal ArticleDOI
Chromosome errors in human eggs shape natural fertility over reproductive life span.
Jennifer R. Gruhn,Agata P. Zielinska,Vallari Shukla,Robert Blanshard,Robert Blanshard,Antonio Capalbo,Danilo Cimadomo,Dmitry Nikiforov,Dmitry Nikiforov,Andrew Chi-Ho Chan,Louise Newnham,Ivan Vogel,Catello Scarica,Marta Krapchev,Deborah M. Taylor,Stine Gry Kristensen,Junping Cheng,Erik Ernst,Anne Mette Bay Bjørn,Lotte Berdiin Colmorn,Martyn Blayney,Kay Elder,Joanna Liss,Geraldine M. Hartshorne,Marie Louise Grøndahl,Laura Rienzi,Filippo Ubaldi,Rajiv C. McCoy,Krzysztof Lukaszuk,Krzysztof Lukaszuk,Claus Andersen,Melina Schuh,Eva Hoffmann +32 more
TL;DR: The authors show that chromosome structure erodes only with advancing age, acting as a “molecular clock” for reproductive senescence, and suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.
Journal ArticleDOI
A Mec1- and PP4-Dependent Checkpoint Couples Centromere Pairing to Meiotic Recombination
TL;DR: The centromeric localization and persistent activity of PP4 during meiotic prophase suggest a model whereby Zip1-S75 phosphorylation dynamically destabilizes homology-independent centromere pairing in response to recombination initiation, thereby coupling meiotic chromosome dynamics to DSB repair.
Journal ArticleDOI
Chromosome Errors in Human Eggs Shape Natural Fertility Over Reproductive Life Span
Jennifer R. Gruhn,Agata P. Zielinska,Vallari Shukla,Robert Blanshard,Antonio Capalbo,Danilo Cimadomo,Dmitry Nikiforov,Andrew Chi-Ho Chan,Louise Newnham,Ivan Vogel,Catello Scarica,Marta Krapchev,Deborah M. Taylor,Stine Gry Kristensen,Junping Cheng,Erik Ernst,Anne Mette Bay Bjørn,Lotte Berdiin Colmorn,Martyn Blayney,Kay Elder,Joanna Liss,Geraldine M. Hartshorne,Marie Louise Grøndahl,Laura Rienzi,Filippo Ubaldi,Rajiv C. McCoy,Krzysztof Lukaszuk,Claus Andersen,Melina Schuh,Eva Hoffmann +29 more
TL;DR: The study results show an increase in precocious separation of sister chromatids and RS derived from localized centromeric and systemic cohesion weakening as women age, suggesting cohesion weakening may act as a “molecular clock” limiting reproductive capacity in AMAs.
Journal ArticleDOI
Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions.
Alice Copsey,Shangming Tang,Philip W. Jordan,Hannah G. Blitzblau,Sonya Newcombe,Andrew Chi-Ho Chan,Louise Newnham,Zhaobo Li,Stephen Gray,Alex Herbert,Prakash Arumugam,Andreas Hochwagen,Neil Hunter,Eva Hoffmann +13 more
TL;DR: The data suggest that the Smc5/6 complex is required for specific recombination and chromosomal processes throughout meiosis and that in its absence, attempts at cell division with unresolved joint molecules and residual cohesin lead to severe recombination-induced meiotic catastrophe.
Journal ArticleDOI
Temperature-Dependent Modulation of Chromosome Segregation in msh4 Mutants of Budding Yeast
TL;DR: Interactions between genetic (zmm status) and environmental factors in determining chromosome segregation are demonstrated and another ZMM protein, Zip1, is important for the temperature-dependent improvement in spore viability.