Ivan Vogel

TL;DR: The authors show that chromosome structure erodes only with advancing age, acting as a “molecular clock” for reproductive senescence, and suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.

TL;DR: The study results show an increase in precocious separation of sister chromatids and RS derived from localized centromeric and systemic cohesion weakening as women age, suggesting cohesion weakening may act as a “molecular clock” limiting reproductive capacity in AMAs.

TL;DR: It is demonstrated that RTEL1 (regulator of telomere elongation helicase 1) has a genome-wide role in MiDAS at loci prone to form G-quadruplex-associated R-loops, in a process that is dependent on its helicase function and suggested thatRTEL1 maintains genome stability by resolving conflicts that can arise between the replication and transcription machineries.

TL;DR: It is demonstrated that transient stalling at this barrier induces a distinct pattern of genome rearrangements in the newly replicated region behind the stalled fork, which primarily consist of localized losses and duplications of DNA sequences.

TL;DR: This article reviews the genetic changes present in cancer cells that influence oncogene-induced RS and CIN, with a particular emphasis on regions of the human genome that show enhanced sensitivity to the destabilizing effects of RS, such as common fragile sites.