L
Lambert K. Sørensen
Researcher at Aarhus University
Publications - 26
Citations - 1287
Lambert K. Sørensen is an academic researcher from Aarhus University. The author has contributed to research in topics: Tandem mass spectrometry & Hydrophilic interaction chromatography. The author has an hindex of 14, co-authored 23 publications receiving 873 citations. Previous affiliations of Lambert K. Sørensen include Aarhus University Hospital.
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Journal ArticleDOI
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.
Markus Hoffmann,Heike Hofmann-Winkler,Joan C. Smith,Nadine Krüger,Prerna Arora,Lambert K. Sørensen,Ole S. Søgaard,Jørgen B. Hasselstrøm,Michael Winkler,Tim Hempel,Lluís Raich,Simon Olsson,Olga Danov,Danny Jonigk,Takashi Yamazoe,Katsura Yamatsuta,Hirotaka Mizuno,Stephan Ludwig,Frank Noé,Mads Kjolby,Armin Braun,Jason M. Sheltzer,Stefan Pöhlmann +22 more
TL;DR: In this article, the authors showed that several TMPRSS2-related proteases activate SARS-CoV-2 and that two of them are robustly expressed in the upper respiratory tract and can be blocked by Camostat mesylate and its metabolite GBPA.
Journal ArticleDOI
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
Kasper L Jønsson,Anders Laustsen,Christian Krapp,Christian Krapp,Kristian Alsbjerg Skipper,Karthiga Thavachelvam,Dominik Hotter,Johanne H Egedal,Mads Kjolby,Mads Kjolby,Pejman Mohammadi,Thaneas Prabakaran,Lambert K. Sørensen,Chenglong Sun,Søren B. Jensen,Christian K. Holm,Robert Jan Lebbink,Mogens Johannsen,Mette Nyegaard,Jacob Giehm Mikkelsen,Frank Kirchhoff,Søren R. Paludan,Martin R. Jakobsen +22 more
TL;DR: The results suggest that IFI16 is essential for efficient sensing and signalling upon DNA challenge in macrophages to promote interferons and antiviral responses.
Journal ArticleDOI
cGAS is activated by DNA in a length-dependent manner.
Stefanie Luecke,Andreas Holleufer,Maria H Christensen,Kasper L Jønsson,Gerardo A Boni,Lambert K. Sørensen,Mogens Johannsen,Martin R. Jakobsen,Rune Hartmann,Søren R. Paludan +9 more
TL;DR: In vitro studies reveal that long DNA activates recombinant human cGAS more efficiently than short DNA, showing that length‐dependent DNA recognition is an intrinsic property of cGas independent of accessory proteins.
Journal ArticleDOI
Determination of cathinones and related ephedrines in forensic whole-blood samples by liquid-chromatography-electrospray tandem mass spectrometry.
TL;DR: A liquid-chromatography-tandem-mass-spectrometry method using pneumatically assisted electrospray ionisation (LC-ESI-MS/MS) was developed for the simultaneous determination of cathinone, methcathinone and methylephedrine in human live and post-mortem whole blood as mentioned in this paper.
Posted ContentDOI
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity
Markus Hoffmann,Heike Hofmann-Winkler,Joan C. Smith,Joan C. Smith,Nadine Krüger,Lambert K. Sørensen,Ole Schmeltz Søgaard,Ole Schmeltz Søgaard,Jørgen B. Hasselstrøm,Michael Winkler,Tim Hempel,Lluís Raich,Simon Olsson,Takashi Yamazoe,Katsura Yamatsuta,Hirotaka Mizuno,Stephan Ludwig,Frank Noé,Frank Noé,Jason M. Sheltzer,Mads Kjolby,Mads Kjolby,Stefan Pöhlmann +22 more
TL;DR: It is shown that SARS-CoV-2 can employ TMPRSS2-related host cell proteases for activation and that several of them are expressed in viral target cells, however, entry mediated by these proteases was blocked by camostat mesylate.