C
Cesar Sommer
Researcher at Boston University
Publications - 46
Citations - 3901
Cesar Sommer is an academic researcher from Boston University. The author has contributed to research in topics: Induced pluripotent stem cell & Chimeric antigen receptor. The author has an hindex of 21, co-authored 44 publications receiving 3550 citations. Previous affiliations of Cesar Sommer include Boston Medical Center & Federal University of São Carlos.
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Journal ArticleDOI
Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells
Kian Peng Koh,Akiko Yabuuchi,Sridhar Rao,Yun Huang,Kerrianne Cunniff,Julie Nardone,Asta Laiho,Mamta Tahiliani,Cesar Sommer,Gustavo Mostoslavsky,Riitta Lahesmaa,Riitta Lahesmaa,Stuart H. Orkin,Stuart H. Orkin,Stuart H. Orkin,Scott J. Rodig,George Q. Daley,Anjana Rao +17 more
TL;DR: 5hmC is an epigenetic modification associated with the pluripotent state, and Tet1 functions to regulate the lineage differentiation potential of ESCs.
Journal ArticleDOI
Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette
Cesar Sommer,Matthias Stadtfeld,George J. Murphy,Konrad Hochedlinger,Darrell N. Kotton,Gustavo Mostoslavsky +5 more
TL;DR: Using a single lentiviral vector expressing a “stem cell cassette” composed of the four transcription factors and a combination of 2A peptide and internal ribosome entry site technology achieves the most efficient reprogramming system to date and allows derivation of iPS cells with a single viral integration.
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Generation of Transgene‐Free Lung Disease‐Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette
Aba Somers,Jyh-Chang Jean,Cesar Sommer,Amel Omari,Christopher C. Ford,Jason A. Mills,Lei Ying,Andreia Gianotti Sommer,Jenny M. Jean,Brenden W. Smith,Robert Lafyatis,Marie-France Demierre,Daniel J. Weiss,Deborah L. French,Paul Gadue,George J. Murphy,Gustavo Mostoslavsky,Darrell N. Kotton +17 more
TL;DR: It is demonstrated that human iPSC generated with the use of a humanized version of a single lentiviral “stem cell cassette” vector have the ability to robustly differentiate into definitive endoderm in vitro, the developmental precursor tissue of lung epithelia.
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Reprogramming of human peripheral blood cells to induced pluripotent stem cells.
Judith Staerk,Meelad M. Dawlaty,Qing Gao,Dorothea Maetzel,Jacob H. Hanna,Cesar Sommer,Gustavo Mostoslavsky,Rudolf Jaenisch +7 more
TL;DR: A polycistronic vector encoding Oct4, Klf4, Sox2 and c-Myc is used to generate iPS cells from from frozen peripheral blood of several donors and these cells were derived from mature T cells as well as myeloid donor cells.
Journal ArticleDOI
Excision of Reprogramming Transgenes Improves the Differentiation Potential of iPS Cells Generated with a Single Excisable Vector
Cesar Sommer,Andreia Gianotti Sommer,Tyler A. Longmire,Constantina Christodoulou,Dolly D. Thomas,Monica Gostissa,Frederick W. Alt,George J. Murphy,Darrell N. Kotton,Gustavo Mostoslavsky +9 more
TL;DR: It is found that removal of the reprogramming vector markedly improves the developmental potential of iPS cells and significantly augments their capacity to undergo directed differentiation in vitro.