David C. Page

TL;DR: In testes of wildtype mice, Dazh transcription is detectable 1 day after birth, increases steadily as spermatogonial stem cells appear, plateaus as the first wave of sperMatogenic cells enters meiosis, and is sustained at this level thereafter, suggesting that DazH participates in differentiation, proliferation, or maintenance of germ cell founder populations before, during, and after the pubertal onset of sPermatogenesis.

TL;DR: It is demonstrated that periodic RA–STRA8 signaling intersects with periodic germ-cell competencies to regulate two distinct, cell-type-specific responses: spermatogonial differentiation and meiotic initiation, and contributes to the prodigious output of spermatozoa and to the elaborate organization of sperMatogenesis.

TL;DR: The identification of TEX11 as the first X-encoded meiosis-specific factor in mice is reported, which promotes initiation and/or maintenance of synapsis and formation of crossovers, and may provide a physical link between these two meiotic processes.

TL;DR: The goals of this work are to understand the computational complexity of the multiple instance regression task and develop an efficient algorithm that is superior to ordinary multiple regression when applied to multiple instance data sets.

TL;DR: The generation of induced embryonic Sertoli-like cells (ieSCs) by ectopic expression of five transcription factors is demonstrated and the role of specific transcription factor combinations in the transition from fibroblasts to ieSCs is characterized and key steps in the process are identified.