D
David C. Page
Researcher at Massachusetts Institute of Technology
Publications - 523
Citations - 47344
David C. Page is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Y chromosome & X chromosome. The author has an hindex of 110, co-authored 509 publications receiving 44119 citations. Previous affiliations of David C. Page include Hennepin County Medical Center & University of California, Los Angeles.
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Journal ArticleDOI
Occurrence of a transposition from the X-chromosome long arm to the Y-chromosome short arm during human evolution
TL;DR: DXYS1, a site showing greater than 99% DNA sequence homology between the human X and Y chromosomes, maps to the X long arm and to the Y short arm, suggesting an X–Y transposition during human evolution.
Journal Article
Gonadoblastoma: molecular definition of the susceptibility region on the Y chromosome.
TL;DR: Although the results do not directly implicate TSPY or YRRM in the etiology of the tumor, they raise the issue of whether there is one GBY gene in the critical region or possibly multiple GBY loci dispersed on the Y chromosome.
Journal ArticleDOI
Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome.
Bruce T. Lahn,David C. Page +1 more
TL;DR: The data indicate that CDY genes arose during primate evolution by retroposition of a CDYL mRNA and amplification of the retroposed gene, which contributed to the gene content of the human Y chromosome, together with two other molecular evolutionary processes.
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A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region
Sjoerd Repping,Sjoerd Repping,Saskia K.M. van Daalen,Cindy M. Korver,Laura G. Brown,Janet D. Marszalek,Judith Gianotten,Robert D. Oates,Sherman J. Silber,Fulco van der Veen,David C. Page,Steve Rozen +11 more
TL;DR: The present findings suggest either that the b2/b3 deletion has at most a modest effect on fitness or that, within branch N, its effect has been counterbalanced by another genetic, possibly Y-linked, factor.
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Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition
Daniel W. Bellott,Helen Skaletsky,Tatyana Pyntikova,Elaine R. Mardis,Tina Graves,Colin Kremitzki,Laura G. Brown,Steve Rozen,Wesley C. Warren,Richard K. Wilson,David C. Page +10 more
TL;DR: It is concluded that the avian Z and mammalian X chromosomes followed convergent evolutionary trajectories, despite their evolving with opposite (female versus male) systems of heterogamety.