D
David C. Page
Researcher at Massachusetts Institute of Technology
Publications - 523
Citations - 47344
David C. Page is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Y chromosome & X chromosome. The author has an hindex of 110, co-authored 509 publications receiving 44119 citations. Previous affiliations of David C. Page include Hennepin County Medical Center & University of California, Los Angeles.
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Journal ArticleDOI
Inactivation of the Rps4 gene on the mouse X chromosome.
Andrew R. Zinn,Steven L. Bressler,Peggy Beer-Romero,Peggy Beer-Romero,David A. Adler,Verne M. Chapman,David C. Page,David C. Page,Christine M. Disteche +8 more
TL;DR: It is reported that mouse Rps4, unlike human RPS4X, is subject to X inactivation, which may explain, at least in part, why the phenotypic consequences of X monosomy are less severe in mice than in humans.
Journal ArticleDOI
Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis.
Thomas A. Natoli,Julia A. Alberta,Alex Bortvin,Alex Bortvin,Mary E. Taglienti,Douglas B. Menke,Douglas B. Menke,Jan Loring,Rudolf Jaenisch,David C. Page,David C. Page,David E. Housman,Jordan A. Kreidberg,Jordan A. Kreidberg +13 more
TL;DR: The Wilms' tumor suppressor gene, Wt1, encodes a transcription factor critical for development of the urogenital system that plays important, and in some cases previously unrecognized, roles in multiple lineages during Urogenital development.
Posted Content
Unachievable Region in Precision-Recall Space and Its Effect on Empirical Evaluation
TL;DR: There is a region of PR space that is completely unachievable, and the size of this region depends only on the skew, and its implications for empirical evaluation methodology in machine learning are discussed.
Journal ArticleDOI
Integration of transcript and genetic maps of chromosome 16 at near-1-Mb resolution: demonstration of a "hot spot" for recombination at 16p12.
David F. Callen,S.A. Lane,H. Kozman,Gabriel Kremmidiotis,S.A. Whitmore,Lowenstein M,Norman A. Doggett,Naoya Kenmochi,David C. Page,Donna R. Maglott +9 more
TL;DR: A correlation between genetic and physical distance over a region estimated to be 23 Mb on the short arm of chromosome 16 identified an interval demonstrating a greatly increased rate of recombination where, in females, 1 cM is equivalent to a physical distance of 100 kb.
Journal ArticleDOI
GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability
Gregoriy A Dokshin,Gregory M. Davis,Ashley Sawle,Matthew D. Eldridge,Peter K. Nicholls,Taylin E. Gourley,Katherine A. Romer,Luke W. Molesworth,Hannah R. Tatnell,Ahmet R. Ozturk,Dirk G. de Rooij,Dirk G. de Rooij,Dirk G. de Rooij,Gregory J. Hannon,Gregory J. Hannon,David C. Page,David C. Page,Craig C. Mello,Michelle A. Carmell,Michelle A. Carmell,Michelle A. Carmell +20 more
TL;DR: It is shown that GCNA and topoisomerase II (TOP2) physically interact in both mice and worms and colocalize on condensed chromosomes during mitosis in C. elegans embryos, which supports a model in which GCNA provides genome maintenance functions in the germline and may do so, in part, by promoting the resolution of TOP2 DPCs.