D
David C. Page
Researcher at Massachusetts Institute of Technology
Publications - 523
Citations - 47344
David C. Page is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Y chromosome & X chromosome. The author has an hindex of 110, co-authored 509 publications receiving 44119 citations. Previous affiliations of David C. Page include Hennepin County Medical Center & University of California, Los Angeles.
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Journal ArticleDOI
A Deletion Map of the Human Y Chromosome Based on DNA Hybridization
Gilles Vergnaud,David C. Page,Marie-Christine Simmler,Laura J. E. Brown,François Rouyer,Bernard Noel,David Botstein,Albert de la Chapelle,Jean Weissenbach +8 more
Journal ArticleDOI
Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave.
TL;DR: The initiation of germ cell sexual differentiation in XX gonads is traced using the Stra8 gene, which is demonstrated to be an early molecular marker of female germ cell development and to progress in an anterior-to-posterior pattern that may reflect local environmental cues that are present in the embryonic XX gonad.
Journal Article
A deletion map of the human Y chromosome based on DNA hybridization.
Gilles Vergnaud,David C. Page,Marie-Christine Simmler,L.G. Brown,François Rouyer,Bernard Noel,David Botstein,de la Chapelle A,Jean Weissenbach +8 more
TL;DR: The results suggest a deletion map of the Y chromosome, in which each of the 23 Y-specific restriction fragments tested can be assigned to one of seven intervals, and the polarity of this map with respect to the long and short arms of theY chromosome is established.
Journal ArticleDOI
The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression.
Jacob L. Mueller,Shantha K. Mahadevaiah,Peter J. Park,Peter E. Warburton,David C. Page,James M. A. Turner +5 more
TL;DR: It is reported that 33 multicopy gene families, representing ∼273 mouse X-linked genes, are expressed in the testis and that this expression is predominantly in postmeiotic cells, and RNA FISH and microarray analysis show that the maintenance of X chromosome postmeiotics repression is incomplete.
Journal ArticleDOI
ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation
Ansbert Schneider-Gädicke,Ansbert Schneider-Gädicke,Peggy Beer-Romero,Peggy Beer-Romero,Laura G. Brown,Laura G. Brown,Robert Nussbaum,David C. Page,David C. Page +8 more
TL;DR: Transcription analysis of human-rodent hybrid cell lines containing "inactive" human X chromosomes suggests that ZFX escapes X inactivation, which contradicts the "dosage/X-inactivation" model, which postulated that sex is determined by the total amount of functionally interchangeable ZFY and ZFX proteins.