D
David E. Nelson
Researcher at Middle Tennessee State University
Publications - 28
Citations - 2660
David E. Nelson is an academic researcher from Middle Tennessee State University. The author has contributed to research in topics: Intracellular parasite & Cryptococcus neoformans. The author has an hindex of 15, co-authored 27 publications receiving 2423 citations. Previous affiliations of David E. Nelson include University of Cambridge & University of Liverpool.
Papers
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Journal ArticleDOI
Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
David E. Nelson,Adaoha E. C. Ihekwaba,M Elliott,James R. Johnson,C. A. Gibney,B. E. Foreman,Glyn Nelson,Violaine Sée,Caroline A. Horton,David G. Spiller,Steven W. Edwards,H. P. McDowell,John Unitt,Elaine Sullivan,Rachel L. Grimley,Neil Benson,David S. Broomhead,Douglas B. Kell,Michael R. H. White +18 more
TL;DR: Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IκBα transcription.
Journal ArticleDOI
Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription
Louise Ashall,Caroline A. Horton,David E. Nelson,Pawel Paszek,Claire V. Harper,Kate Sillitoe,Sheila Ryan,David G. Spiller,John Unitt,David S. Broomhead,Douglas B. Kell,David A. Rand,Violaine Sée,Michael R. H. White +13 more
TL;DR: Altering the stimulation intervals gave different patterns of NF-κB–dependent gene expression, which supports the idea that oscillation frequency has a functional role in nuclear factor κB regulation.
Journal ArticleDOI
The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy
Victoria S Burchell,David E. Nelson,Alvaro Sanchez-Martinez,Alvaro Sanchez-Martinez,Marta Delgado-Camprubi,Rachael M. Ivatt,Rachael M. Ivatt,Joe H. Pogson,Joe H. Pogson,Suzanne J. Randle,Selina Wray,Patrick A. Lewis,Henry Houlden,Andrey Y. Abramov,John Hardy,Nicholas W. Wood,Alexander J. Whitworth,Alexander J. Whitworth,Heike Laman,Helene Plun-Favreau +19 more
TL;DR: It is shown that Fbxo7 participates in mitochondrial maintenance through direct interaction with PINK1 and Parkin and acts in Parkin-mediated mitophagy, emphasizing the importance of mitochondrial dysfunction in Parkinson's disease pathogenesis.
Journal ArticleDOI
Physiological levels of TNFα stimulation induce stochastic dynamics of NF-κB responses in single living cells
David A. Turner,Pawel Paszek,Dan J. Woodcock,David E. Nelson,Caroline A. Horton,Yunjiao Wang,David G. Spiller,David A. Rand,Michael R. H. White,Claire V. Harper +9 more
TL;DR: Deterministic and stochastic models simulated the experimentally observed activation threshold and gave rise to new predictions about the structure of the system and open the way for better mechanistic understanding of physiological TNFα activation of inflammatory responses in cells and tissues.
Journal ArticleDOI
Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins
TL;DR: It is postulate that a few extraordinary FBPs act as platforms that seamlessly segue their canonical and non-canonical functions to integrate different cellular pathways and link their regulation.