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Caroline A. Horton
Researcher at University of Liverpool
Publications - 11
Citations - 1945
Caroline A. Horton is an academic researcher from University of Liverpool. The author has contributed to research in topics: Transcription factor & Population. The author has an hindex of 8, co-authored 11 publications receiving 1809 citations.
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Journal ArticleDOI
Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
David E. Nelson,Adaoha E. C. Ihekwaba,M Elliott,James R. Johnson,C. A. Gibney,B. E. Foreman,Glyn Nelson,Violaine Sée,Caroline A. Horton,David G. Spiller,Steven W. Edwards,H. P. McDowell,John Unitt,Elaine Sullivan,Rachel L. Grimley,Neil Benson,David S. Broomhead,Douglas B. Kell,Michael R. H. White +18 more
TL;DR: Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IκBα transcription.
Journal ArticleDOI
Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription
Louise Ashall,Caroline A. Horton,David E. Nelson,Pawel Paszek,Claire V. Harper,Kate Sillitoe,Sheila Ryan,David G. Spiller,John Unitt,David S. Broomhead,Douglas B. Kell,David A. Rand,Violaine Sée,Michael R. H. White +13 more
TL;DR: Altering the stimulation intervals gave different patterns of NF-κB–dependent gene expression, which supports the idea that oscillation frequency has a functional role in nuclear factor κB regulation.
Journal ArticleDOI
Physiological levels of TNFα stimulation induce stochastic dynamics of NF-κB responses in single living cells
David A. Turner,Pawel Paszek,Dan J. Woodcock,David E. Nelson,Caroline A. Horton,Yunjiao Wang,David G. Spiller,David A. Rand,Michael R. H. White,Claire V. Harper +9 more
TL;DR: Deterministic and stochastic models simulated the experimentally observed activation threshold and gave rise to new predictions about the structure of the system and open the way for better mechanistic understanding of physiological TNFα activation of inflammatory responses in cells and tissues.
Journal ArticleDOI
Interactions among oscillatory pathways in NF-kappa B signaling.
Yunjiao Wang,Yunjiao Wang,Pawel Paszek,Caroline A. Horton,Douglas B. Kell,Michael R. H. White,David S. Broomhead,Mark Muldoon +7 more
TL;DR: Numerical results suggest that the entrainment phenomena observed in pulse-stimulated experiments is a consequence of the high intensity of the stimulation of the NF-kappa B system.
Journal ArticleDOI
Single live-cell imaging for systems biology.
TL;DR: Live-cell imaging and computational modelling are compatible techniques which allow quantitative analysis of cell signalling pathway dynamics, facilitating the identification of important qualitative and quantitative relationships-linking intracellular signalling, gene expression and cell fate.