Noninvasive Assessment of Arterial Stiffness and Risk of Atherosclerotic Events
James Oliver,David J. Webb +1 more
TLDR
The effects of current and future cardiovascular drugs on arterial stiffness are discussed, as is the relationship between arterial elasticity and endothelial function.Abstract:
Investigation of arterial stiffness, especially of the large arteries, has gathered pace in recent years with the development of readily available noninvasive assessment techniques. These include the measurement of pulse wave velocity, the use of ultrasound to relate the change in diameter or area of an artery to distending pressure, and analysis of arterial waveforms obtained by applanation tonometry. Here, we describe each of these techniques and their limitations and discuss how the measured parameters relate to established cardiovascular risk factors and clinical outcome. We also consider which techniques might be most appropriate for wider clinical application. Finally, the effects of current and future cardiovascular drugs on arterial stiffness are also discussed, as is the relationship between arterial elasticity and endothelial function.read more
Citations
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Journal ArticleDOI
Expert consensus document on arterial stiffness: methodological issues and clinical applications
Stéphane Laurent,John R. Cockcroft,Luc M. Van Bortel,Pierre Boutouyrie,Cristina Giannattasio,Daniel Hayoz,Bruno Pannier,Charalambos Vlachopoulos,Ian B. Wilkinson,Harry A.J. Struijker-Boudier +9 more
TL;DR: This paper summarizes the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and is aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.
Journal Article
Expert consensus document on arterial stiffness : methodological issues and clinical applications. Commentary
Michael F. O'Rourke,Stanley S. Franklin,Stéphane Laurent,John R. Cockcroft,Luc M. Van Bortel,Pierre Boutouyrie,Cristina Giannattasio,Daniel Hayoz,Bruno Pannier,Charalambos Vlachopoulos,Ian B. Wilkinson,Harry A.J. Struijker-Boudier +11 more
TL;DR: In this paper, the authors summarized the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.
Journal ArticleDOI
The clinical implications of endothelial dysfunction.
TL;DR: This work suggests that studies of endothelial function could be used in the care of patients and as a surrogate marker for the evaluation of new therapeutic strategies, and a growing number of interventions known to reduce cardiovascular risk have been shown to improve endothelialfunction.
Journal ArticleDOI
Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness
TL;DR: A number of lifestyle changes and therapies that reduce arterial stiffness are presented, including weight loss, exercise, salt reduction, alcohol consumption, and neuroendocrine-directed therapies, such as those targeting the renin-angiotensin aldosterone system, natriuretic peptides, insulin modulators, as well as novel therapies that target advanced glycation end products.
Journal ArticleDOI
Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: A statement by the working group on endothelin and endothelial factors of the European society of hypertension
John E. Deanfield,Ann E. Donald,Claudio Ferri,Cristina Giannattasio,Julian Halcox,Sean Halligan,Amir Lerman,Giuseppe Mancia,Giuseppe Mancia,James Oliver,Achille C. Pessina,Damiano Rizzoni,Gian Paolo Rossi,Antonio Salvetti,Ernesto L. Schiffrin,Stefano Taddei,David J. Webb +16 more
TL;DR: The most relevant methodological issues in the research on endothelial function and dysfunction are summarized in this paper.
References
More filters
Journal ArticleDOI
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.
TL;DR: Throughout middle and old age, usual blood pressure is strongly and directly related to vascular (and overall) mortality, without any evidence of a threshold down to at least 115/75 mm Hg.
Journal Article
The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure
Journal ArticleDOI
Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients.
Stéphane Laurent,Pierre Boutouyrie,Roland Asmar,Isabelle Gautier,Brigitte Laloux,Louis Guize,Pierre Ducimetière,Athanase Benetos +7 more
TL;DR: This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension.
Journal ArticleDOI
Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension *
Jan A. Staessen,Robert Fagard,Lutgarde Thijs,Hilde Celis,G G Arabidze,Willem H. Birkenhäger,Christopher J. Bulpitt,P. W. De Leeuw,Colin T. Dollery,Astrid E. Fletcher,Françoise Forette,Gastone Leonetti,C Nachev,ET O'Brien,Joseph B. Rosenfeld,Jose L. Rodicio,Jaakko Tuomilehto,Alberto Zanchetti +17 more
TL;DR: Among elderly patients with isolated systolic hypertension, antihypertensive drug treatment starting with nitrendipine reduces the rate of cardiovascular complications and may prevent 29 strokes or 53 major cardiovascular endpoints.
The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (NIH Publication No. 98-4080)
Black Hr,Cohen Jd,Kaplan Nm,Ferdinand Kc,Chobanian Av,Dustan Hp,Gifford Rw,M. Moser,Sheps Sg,L. Agodoa,August Pa,Bakris Gl,V. Burt,W. Busse,Carter Bl,Chesley Fd,J. Cleeman,Cohn Jn,Cregler Ll,C. Crespo,Cushman Wc,J. Cutler,Darrow Md,DeQuattro Vl,Devereux Rb,Dworkin Ld,Elliott Wj,M. Epstein,B. Falkner,Ferrario Cm,Flack Jm,W. Frishman,Frohlich Ed,Green La,Grimm Rh,Hagberg Jm,Hall Wd,J. Handler,S. Havas,Hill Mn,Horan Mj,Hsueh Wa,Hyman Bn,Izzo Jl,K. Jamerson,Kiley Jp,Kochar Ms,Kolasa Km,Krakoff Lr,D. Levy,Lindheimer Md,Luepker Rv,Malone Mel,B. Massie,Materson Bj,J. Merchant,Messerli Fh,Miller Nh,Moore Ma,L. MustoneAlexander,S. Oparil,Perry Hm,Pickering Tg,Pratt Jh,Ram Cvs,Randall Os,Reed Jw,Roberts Rw,Roccella Ej,Rogus Sd,E. Saunders,E. Schron,G. Schwartz,Sibai Bm,D. Snyder,Sowers Jr,J. Stamler,R. Temple,S. Textor,T. Thom,Vidt Dg,M. Weber,Weinberger Mh,R. Weinshilboum,Whelton Pk,Whisnant Jp,Wiebers Do,Winston Mc,Wright Jt,C. Lenfant,L. Casser,Colman Pj,T. Edwards,Feeley Dm,J. Gajewski,D. Levine,W. Manger,Marshall Ec,Nickey Wa,Robert Rw,Secrest Bg,Singer Eh,Wilson Gj,Young Jm,Bachman Jw,Campese Vm,Carr Aa,M. Hand,Holden Dc,Jamieson Mj,S. Julius,Mensah Ga,M. Prisant,Sullivan Jm,Wilson Dj,G. Morosco,Anderson De,D. Waugh +117 more
TL;DR: In older persons, diuretics are preferred and long-acting dihydropyridine calcium antagonists may be considered and specific therapy for patients with LVH, coronary artery disease, and heart failure are outlined.