Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins
Neil C. Rogers,Emma Slack,Alexander D. Edwards,Martijn A. Nolte,Oliver Schulz,Edina Schweighoffer,David L. Williams,Siamon Gordon,Victor L. J. Tybulewicz,Gordon D. Brown,Caetano Reis e Sousa +10 more
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TLDR
It is demonstrated that the beta-glucan receptor Dectin-1, a yeast binding C type lectin known to synergize with TLR2 to induce TNF alpha and IL-12, can also promote synthesis of IL-2 andIL-10 through phosphorylation of the membrane proximal tyrosine in the cytoplasmic domain and recruitment of Syk kinase.About:
This article is published in Immunity.The article was published on 2005-04-01 and is currently open access. It has received 866 citations till now. The article focuses on the topics: Syk & Signal transduction.read more
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
The regulation of IL-10 production by immune cells
Margarida Saraiva,Anne O'Garra +1 more
TL;DR: Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.
Journal ArticleDOI
Toll-like receptors and innate immunity
Satoshi Uematsu,Shizuo Akira +1 more
TL;DR: This review focuses on the functions of PRRs in innate immunity and their downstream signaling cascades and identifies cytoplasmic PRRs to detect pathogens that have invaded cytosols.
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The roles of TLRs, RLRs and NLRs in pathogen recognition
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent insights into pathogen sensing by PRRs are summarized and specific signaling pathways that lead to expression of genes that tailor immune responses to particular microbes are summarized.
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Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
TL;DR: The IL-10 family of cytokines consists of nine members that can promote innate immune responses from tissue epithelia to limit the damage caused by viral and bacterial infections and facilitate the tissue-healing process in injuries caused by infection or inflammation.
References
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TL;DR: Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed.
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Production of high titer helper-free retroviruses by transient transfection
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