D
David Reich
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 695
Citations - 107008
David Reich is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Population & Ancient DNA. The author has an hindex of 137, co-authored 644 publications receiving 91397 citations. Previous affiliations of David Reich include Mount Sinai St. Luke's and Mount Sinai Roosevelt & Howard Hughes Medical Institute.
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Journal ArticleDOI
Reduced Neutrophil Count in People of African Descent Is Due To a Regulatory Variant in the Duffy Antigen Receptor for Chemokines Gene
David Reich,David Reich,Mike A. Nalls,W. H. Linda Kao,Ermeg L. Akylbekova,Arti Tandon,Arti Tandon,Nick Patterson,James C. Mullikin,Wen-Chi Hsueh,Ching-Yu Cheng,Ching-Yu Cheng,Josef Coresh,Eric Boerwinkle,Man Yu Li,Alicja Waliszewska,Alicja Waliszewska,Julie Neubauer,Rongling Li,Tennille S. Leak,Lynette Ekunwe,Joe C. Files,Cheryl L. Hardy,Joseph M. Zmuda,Herman A. Taylor,Herman A. Taylor,Herman A. Taylor,Elad Ziv,Tamara B. Harris,James G. Wilson +29 more
TL;DR: It is confirmed that rs2814778 is predictive of WBC and neutrophil count in African Americans above beyond the previously described admixture association, establishing a novel phenotype for this genetic variant.
Journal ArticleDOI
Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes.
Serhat Aytug,David Reich,Lawrence E. Sapiro,Lawrence E. Sapiro,David I. Bernstein,Najma Begum,Najma Begum +6 more
TL;DR: It is found that HCV infection leads to a postreceptor defect in IRS‐1 association with the IR and insulin signaling defects in hepatic IRS‐ 1 tyrosine phosphorylation and PI3‐kinase association/activation may contribute to insulin resistance, which leads to the development of type 2 diabetes mellitus in patients withHCV infection.
Journal ArticleDOI
Early postnatal dexamethasone treatment and increased incidence of cerebral palsy
Eric S. Shinwell,M Karplus,David Reich,Z Weintraub,S. Blazer,D Bader,S Yurman,T. Dolfin,A Kogan,S Dollberg,E Arbel,Marcel Goldberg,I Gur,N Naor,L Sirota,S Mogilner,A Zaritsky,M. Barak,E Gottfried +18 more
TL;DR: Logistic regression analysis showed both periventricular leucomalacia and drug assignment to dexamethasone to be highly significant predictors of abnormal neurological outcome.
Journal ArticleDOI
Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African Americans
Jorge R. Oksenberg,Lisa F. Barcellos,Bruce A.C. Cree,Sergio E. Baranzini,Teodorica L. Bugawan,Omar Khan,Robin R. Lincoln,Amy Swerdlin,Emmanuel Mignot,Ling Lin,Douglas S. Goodin,Henry A. Erlich,Silke Schmidt,Glenys Thomson,David Reich,Margaret A. Pericak-Vance,Jonathan L. Haines,Stephen L. Hauser +17 more
TL;DR: A selective association with HLA-DRB1*15 was revealed, indicating a primary role for the DRB1 locus in MS independent of DQB1*0602, and is unlikely to be solely explained by admixture, since a substantial proportion of the susceptibility chromosomes from African American patients with MS displayed haplotypes consistent with an African origin.
Journal ArticleDOI
Human genome sequence variation and the influence of gene history, mutation and recombination.
David Reich,Stephen F. Schaffner,Mark J. Daly,Gil McVean,James C. Mullikin,John M. Higgins,Daniel J. Richter,Eric S. Lander,David Altshuler,David Altshuler +9 more
TL;DR: The results are best explained by extreme variability in the recombination rate at a fine scale, and provide the first empirical evidence that such recombination 'hot spots' are a general feature of the human genome and have a principal role in shaping genetic variation in the human population.