D
David Reich
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 695
Citations - 107008
David Reich is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Population & Ancient DNA. The author has an hindex of 137, co-authored 644 publications receiving 91397 citations. Previous affiliations of David Reich include Mount Sinai St. Luke's and Mount Sinai Roosevelt & Howard Hughes Medical Institute.
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Supplementary Information for: The genetic prehistory of southern Africa
Joseph K. Pickrell,Nick Patterson,Chiara Barbieri,Falko Berthold,Linda Gerlach,Blesswell Kure,Hirosi Nakagawa,Christfried Naumann,Mark Lipson,Po-Ru Loh,Joseph Lachance,Joanna L. Mountain,Carlos Bustamante,Bonnie Berger,Sarah Tishko,Brenna M. Henn,Mark Stoneking,David Reich,Brigitte Pakendorf +18 more
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of the MPI for Evolutionary Anthropology, as to provide real-time information about an individual’s TSP.
Posted ContentDOI
Extensive Regulatory Changes in Genes Affecting Vocal and Facial Anatomy Separate Modern from Archaic Humans
David Gokhman,Lily Agranat-Tamir,Genevieve Housman,Raquel García-Pérez,Malka Nissim-Rafinia,Swapan Mallick,Maria A. Nieves-Colón,Heng Li,Songül Alpaslan-Roodenberg,Mario Novak,Mario Novak,Hongcang Gu,Manuel Ferrando-Bernal,Pere Gelabert,Iddi Lipende,Ivanela Kondova,Ronald E. Bontrop,Ellen E. Quillen,Alexander Meissner,Anne C. Stone,Anne E. Pusey,Deus Mjungu,Leonid Kandel,Meir Liebergall,María E. Prada,Julio M. Vidal,Kay Prüfer,Johannes Krause,Benjamin Yakir,Svante Pääbo,Ron Pinhasi,Carles Lalueza-Fox,David Reich,Tomas Marques-Bonet,Eran Meshorer,Liran Carmel +35 more
TL;DR: This work identifies silencing patterns in a network of genes (SOX9, ACAN, COL2A1 and NFIX), and proposes that they might have played a role in the reshaping of the human face, and in forming the 1:1 vocal tract configuration that is considered optimal for speech.
Journal ArticleDOI
Three assays for in-solution enrichment of ancient human DNA at more than a million SNPs
TL;DR: In 2019, two companies, Daicel Arbor Biosciences and Twist Bioscience, made available assays that target the same core set of SNPs along with supplementary content as discussed by the authors .
Journal ArticleDOI
An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro.
Truc M. Le,Alecia Willis,Frederick E. Barr,Frederick E. Barr,Gary Cunningham,Gary Cunningham,Jeffrey A. Canter,Sarah E. Owens,Rachel Apple,George Ayodo,David Reich,Marshall L. Summar +11 more
TL;DR: A glutathione production pathway polymorphism present in individuals of African descent with significantly decreased in vitro activity is reported, and it is demonstrated that apoptotically stimulated mammalian cells overexpressing the 462S enzyme have increased caspase activation and increased DNA laddering compared to cells overexpression of the wild-type 462P enzyme.
Posted ContentDOI
Genes Affecting Vocal and Facial Anatomy Went Through Extensive Regulatory Divergence in Modern Humans
David Gokhman,Malka Nissim-Rafinia,Lily Agranat-Tamir,Genevieve Housman,Raquel García-Pérez,Esther Lizano,Olivia Cheronet,Swapan Mallick,Swapan Mallick,Swapan Mallick,Maria A. Nieves-Colón,Heng Li,Songül Alpaslan-Roodenberg,Mario Novak,Mario Novak,Hongcang Gu,Jason M. Osinski,Manuel Ferrando-Bernal,Pere Gelabert,Iddi Lipende,Deus Mjungu,Ivanela Kondova,Ronald E. Bontrop,Ottmar Kullmer,Gerhard W. Weber,Tal Shahar,Mona Dvir-Ginzberg,Marina Faerman,Ellen E. Quillen,Alexander Meissner,Alexander Meissner,Yonatan Lahav,Yonatan Lahav,Leonid Kandel,Meir Liebergall,María E. Prada,Julio M. Vidal,Richard M. Gronostajski,Anne C. Stone,Benjamin Yakir,Carles Lalueza-Fox,Ron Pinhasi,David Reich,David Reich,David Reich,Tomas Marques-Bonet,Eran Meshorer,Liran Carmel +47 more
TL;DR: Widespread hypermethylation in a network of face- and voice-affecting genes is identified and it is proposed that these repression patterns appeared after the split from Neanderthals and Denisovans and that they might have played a key role in shaping the modern human face and vocal tract.