D
David Reich
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 695
Citations - 107008
David Reich is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Population & Ancient DNA. The author has an hindex of 137, co-authored 644 publications receiving 91397 citations. Previous affiliations of David Reich include Mount Sinai St. Luke's and Mount Sinai Roosevelt & Howard Hughes Medical Institute.
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Journal ArticleDOI
No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans
TL;DR: Simulations show that the observed patterns are not likely to reflect changes in the effectiveness of selection after the populations split but are instead likely to be driven by other population genetic factors.
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Archaeogenomic evidence reveals prehistoric matrilineal dynasty
Douglas J. Kennett,Stephen Plog,Richard George,Brendan J. Culleton,Adam S. Watson,Pontus Skoglund,Nadin Rohland,Swapan Mallick,Swapan Mallick,Swapan Mallick,Kristin Stewardson,Kristin Stewardson,Logan Kistler,Logan Kistler,Steven A. LeBlanc,Peter M. Whiteley,David Reich,David Reich,David Reich,George H. Perry +19 more
TL;DR: It is shown that nine individuals buried in an elite crypt at Pueblo Bonito, the largest structure in the canyon, have identical mitochondrial genomes, andalyses of nuclear genome data from six samples with the highest DNA preservation demonstrate mother–daughter and grandmother–grandson relationships, evidence for a multigenerational matrilineal descent group.
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Reconstructing the genetic history of late Neanderthals
Mateja Hajdinjak,Qiaomei Fu,Qiaomei Fu,Alexander Hübner,Martin Petr,Fabrizio Mafessoni,Steffi Grote,Pontus Skoglund,Vagheesh Narasimham,Hélène Rougier,Isabelle Crevecoeur,Patrick Semal,Marie Soressi,Sahra Talamo,Jean-Jacques Hublin,Ivan Gušić,Željko Kućan,Pavao Rudan,Liubov V. Golovanova,Vladimir B. Doronichev,Cosimo Posth,Johannes Krause,Petra Korlević,Sarah Nagel,Birgit Nickel,Montgomery Slatkin,Nick Patterson,Nick Patterson,David Reich,David Reich,David Reich,Kay Prüfer,Matthias Meyer,Svante Pääbo,Janet Kelso +34 more
TL;DR: It is found that the bulk of Neanderthal gene flow into early modern humans originated from one or more source populations that diverged from the Neanderthals that were studied here at least 70,000 years ago, but after they split from a previously sequenced Neanderthal from Siberia around 150,000 year ago.
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Early On–Cardiopulmonary Bypass Hypotension and Other Factors Associated With Vasoplegic Syndrome
Matthew A. Levin,Hung-Mo Lin,Javier G. Castillo,David H. Adams,David Reich,Gregory W. Fischer +5 more
TL;DR: It is suggested that it is possible to predict vasoplegia intraoperatively before separation from CPB and that the presence of a clinically significant area above the mean arterial blood pressure curve serves as a predictor of poor clinical outcome.
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The role of the CD58 locus in multiple sclerosis
Philip L. De Jager,Clare Baecher-Allan,Lisa M. Maier,Ariel T. Arthur,Linda Ottoboni,Linda Ottoboni,Lisa F. Barcellos,Jacob L. McCauley,Stephen Sawcer,An Goris,Janna Saarela,Roman Yelensky,Alkes L. Price,Virpi Leppa,Nick Patterson,Paul I.W. de Bakker,Dong Tran,Cristin Aubin,Susan Pobywajlo,Elizabeth J. Rossin,Xinli Hu,Charles Ashley,Edwin Choy,John D. Rioux,John D. Rioux,Margaret A. Pericak-Vance,Adrian J. Ivinson,David R. Booth,Graeme J. Stewart,Aarno Palotie,Leena Peltonen,Bénédicte Dubois,Jonathan L. Haines,Howard L. Weiner,Alastair Compston,Stephen L. Hauser,Mark J. Daly,David Reich,Jorge R. Oksenberg,David A. Hafler +39 more
TL;DR: Functional investigations suggest a potential mechanism whereby increases in CD58 expression, mediated by the protective allele, up-regulate the expression of transcription factor FoxP3 through engagement of the CD58 receptor, CD2, leading to the enhanced function of CD4+CD25high regulatory T cells that are defective in subjects with MS.