D
David Reich
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 695
Citations - 107008
David Reich is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Population & Ancient DNA. The author has an hindex of 137, co-authored 644 publications receiving 91397 citations. Previous affiliations of David Reich include Mount Sinai St. Luke's and Mount Sinai Roosevelt & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
A retrospective analysis of the costs and benefits related to alterations in cardiac surgery from routine intraoperative transesophageal echocardiography.
TL;DR: A review of 430 adult cardiac surgical records indicates that routine transesophageal echocardiography during cardiac surgery, including coronary artery surgery, is beneficial and cost-effective.
Journal ArticleDOI
Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population
Desmond Campbell,María Victoria Parra,María Victoria Parra,Constanza Duque,Constanza Duque,Natalia Gallego,Liliana Franco,Arti Tandon,Tábita Hünemeier,Cátira Bortolini,Alberto Villegas,Gabriel Bedoya,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Alkes L. Price,David Reich,David Reich,Andres Ruiz-Linares +18 more
TL;DR: The “thrifty genotype” hypothesis proposes that the high prevalence of type 2 diabetes in Native Americans and admixed Latin Americans has a genetic basis and reflects an evolutionary adaptation to a past low calorie/high exercise lifestyle, but identification of the gene variants underpinning this hypothesis remains elusive.
Journal ArticleDOI
Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes.
Mark Lipson,Po-Ru Loh,Sriram Sankararaman,Sriram Sankararaman,Nick Patterson,Bonnie Berger,Bonnie Berger,David Reich,David Reich,David Reich +9 more
TL;DR: This work proposes a new method that uses the fine-scale human recombination map to calibrate the rate of accumulation of mutations and infer a rate of 1.61 ± 0.13 × 10−8 mutations per base per generation, which falls in between phylogenetic and pedigree-based estimates.
Journal ArticleDOI
Prolonged concurrent hypotension and low bispectral index (‘double low’) are associated with mortality, serious complications, and prolonged hospitalization after cardiac surgery
Ankit Maheshwari,Patrick J. McCormick,D. I. Sessler,David Reich,Jing You,Ed Mascha,Javier G. Castillo,Matthew A. Levin,Andra E. Duncan +8 more
TL;DR: A prolonged concurrent doubleLow, but not a case-averaged double low, was associated with higher morbidity and mortality after cardiac surgery.
Journal ArticleDOI
Haemodynamic responses to tracheal intubation following etomidate and fentanyl for anaesthetic induction.
TL;DR: The authors recommend using fentanyl, 5–10 μg · kg−1 to blunt the haemodynamic response to tracheal intubation following anaesthetic induction with etomidate, 0.3 mg ·kg−1.