D
David S. Reiner
Researcher at University of California, San Diego
Publications - 41
Citations - 3852
David S. Reiner is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Giardia lamblia & Endoplasmic reticulum. The author has an hindex of 30, co-authored 41 publications receiving 3679 citations. Previous affiliations of David S. Reiner include Oklahoma Medical Research Foundation & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia.
Hilary G. Morrison,Andrew G. McArthur,Frances D. Gillin,Stephen B. Aley,Rodney D. Adam,Gary J. Olsen,Aaron A. Best,W. Zacheus Cande,Feng Chen,Michael J. Cipriano,Barbara J. Davids,Scott C. Dawson,Heidi G. Elmendorf,Adrian B. Hehl,Michael Holder,Susan M. Huse,Ulandt Kim,Erica Lasek-Nesselquist,Gerard Manning,Anuranjini Nigam,Julie E. J. Nixon,Daniel Palm,Nora Q.E. Passamaneck,Anjali Prabhu,Claudia I. Reich,David S. Reiner,John Samuelson,Staffan G. Svärd,Mitchell L. Sogin +28 more
TL;DR: The genome of the eukaryotic protist Giardia lamblia, an important human intestinal parasite, is compact in structure and content, contains few introns or mitochondrial relics, and has simplified machinery for DNA replication, transcription, RNA processing, and most metabolic pathways.
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Draft Genome Sequencing of Giardia intestinalis Assemblage B Isolate GS: Is Human Giardiasis Caused by Two Different Species?
Oscar Franzén,Jon Jerlström-Hultqvist,Elsie Castro,Ellen Sherwood,Johan Ankarklev,David S. Reiner,Daniel Palm,Jan Andersson,Björn Andersson,Staffan G. Svärd +9 more
TL;DR: The genomic differences between WB and GS may explain some of the observed biological and clinical differences between the two isolates, and it suggests that assemblage A and B Giardia can be two different species.
Journal ArticleDOI
Cell biology of the primitive eukaryote Giardia lamblia.
TL;DR: It is found that G. lamblia forms novel encystation-specific secretory vesicles and can sort cyst wall proteins to a regulated secretory pathway distinct from the constitutive pathway used to transport the variable cysteine-rich protein to the trophozoite surface.
Journal ArticleDOI
Giardia immunity – an update
Katarina Roxström-Lindquist,Daniel Palm,Daniel Palm,David S. Reiner,David S. Reiner,Emma Ringqvist,Staffan G. Svärd,Staffan G. Svärd +7 more
TL;DR: It is becoming clear that the host defense against a Giardia infection involves several different immunological and non-immunological mucosal processes.
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Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cells.
Emma Ringqvist,J. E. Daniel Palm,J. E. Daniel Palm,Hanna Skarin,Adrian B. Hehl,Malin E.-L. Weiland,Barbara J. Davids,David S. Reiner,David S. Reiner,William J. Griffiths,Lars Eckmann,Frances D. Gillin,Staffan G. Svärd,Staffan G. Svärd +13 more
TL;DR: Results indicate that contact of Giardia with epithelial cells triggers metabolic enzyme release, which might facilitate effective colonization of the human small intestine.