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Giardia immunity – an update

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TLDR
It is becoming clear that the host defense against a Giardia infection involves several different immunological and non-immunological mucosal processes.
About
This article is published in Trends in Parasitology.The article was published on 2006-01-01. It has received 198 citations till now. The article focuses on the topics: Giardia lamblia & Giardia.

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Behind the smile: cell biology and disease mechanisms of Giardia species.

TL;DR: This Review discusses recent discoveries in the molecular cell biology and pathogenesis of G. intestinalis and suggests that the disease mechanisms are still poorly understood.
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Extra-intestinal and long term consequences of Giardia duodenalis infections

TL;DR: A state-of-the-art discussion on the long-term consequences of Giardia infections, from extra-intestinal manifestations, growth and cognitive deficiencies, to post-infectious irritable bowel syndrome is offered.
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Transmission and Epidemiology of Zoonotic Protozoal Diseases of Companion Animals

TL;DR: A review of zoonotic protozoal mechanisms of virulence, epidemiology, and the transmission of pathogens of consequence to pet owners in the United States focused on Giardia and Toxoplasma gondii.
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Giardiasis – why do the symptoms sometimes never stop?

TL;DR: Current knowledge is outlined, based on individual case sequelae from sporadic infections, observations of population effects following outbreaks and studies of phenotypic and genotypic diversity between morphologically identical isolates of parasites, that giardiasis sometimes becomes an intrusive, long-term problem.
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A Systematic Review and Meta-analysis of the Association Between Giardia lamblia and Endemic Pediatric Diarrhea in Developing Countries

TL;DR: In this systematic review and meta-analysis, Giardia lamblia was not associated with acute pediatric diarrhea in nonindustrialized settings but was positively linked to persistent diarrhea.
References
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Journal ArticleDOI

Mast cells in the development of adaptive immune responses

TL;DR: Mast cells may influence the development, intensity and duration of adaptive immune responses that contribute to host defense, allergy and autoimmunity, rather than simply functioning as effector cells in these settings.
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A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

TL;DR: Since the cytokines expressed in response to bacterial invasion or other proinflammatory agonists have a well documented role in chemotaxis and activation of inflammatory cells, colon epithelial cells appear to be programmed to provide a set of signals for the activation of the mucosal inflammatory response in the earliest phases after microbial invasion.
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Biology of Giardia lamblia.

TL;DR: The Giardia genome project promises to greatly increase the understanding of this interesting and enigmatic organism.
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The zoonotic significance and molecular epidemiology of giardia and giardiasis

TL;DR: The taxonomy and molecular epidemiology ofGiardia and Giardia infections are reviewed and the greatest risk of zoonotic transmission appears to be from companion animals such as dogs and cats, although further studies are required in different endemic foci.
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Drinking water treatment processes for removal of Cryptosporidium and Giardia

TL;DR: Technical information on conventional and alternative drinking water treatment technologies for removal and inactivation of the protozoan parasites Cryptosporidium and Giardia is provided.
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