D
De-Chen Lin
Researcher at Cedars-Sinai Medical Center
Publications - 119
Citations - 7530
De-Chen Lin is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Cancer & Epigenomics. The author has an hindex of 36, co-authored 105 publications receiving 4614 citations. Previous affiliations of De-Chen Lin include Sun Yat-sen University & Peking Union Medical College.
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Journal ArticleDOI
Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma.
Xiaoli Du,Hongjun Yang,Shu-Guang Liu,Man-Li Luo,Jia-Jie Hao,Yushan Zhang,De-Chen Lin,Xin Xu,Cai Y,Qi min Zhan,Ming Rong Wang +10 more
TL;DR: A role of CRT in motility promotion and anoikis resistance in ESCC cells is revealed and CRT is identified as an upstream regulator in the CRT–STAT3–CTTN–PI3K–Akt pathway.
Journal ArticleDOI
Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization
Zhi-Zhou Shi,Li Shang,Yan-Yi Jiang,Jia-Jie Hao,Yu Zhang,Tong-Tong Zhang,De-Chen Lin,Shu-Guang Liu,Bo-Shi Wang,Ting Gong,Qimin Zhan,Ming-Rong Wang +11 more
TL;DR: Copy number aberrations in both esophageal dysplasia and ESCC may be useful as potential biomarkers for early detection and ANO1 may be a candidate target gene in esophagal tumorigenesis.
Journal ArticleDOI
Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
Ling-Wen Ding,Qiao-Yang Sun,Kar Tong Tan,Wenwen Chien,Anand Mayakonda Thippeswamy,Allen Eng Juh Yeoh,Norihiko Kawamata,Norihiko Kawamata,Yasunobu Nagata,Jin Fen Xiao,Xin-Yi Loh,De-Chen Lin,De-Chen Lin,Manoj Garg,Manoj Garg,Yan-Yi Jiang,Liang Xu,Su Lin Lim,Li Zhen Liu,Vikas Madan,Masashi Sanada,Lucía Fernández,Hema Preethi,Michael Lill,Hagop M. Kantarjian,Steven M. Kornblau,Satoru Miyano,Der Cherng Liang,Seishi Ogawa,Lee Yung Shih,Henry Yang,H. Phillip Koeffler,H. Phillip Koeffler +32 more
TL;DR: Next-generation sequencing is used to interrogate the genetic and pathogenic mechanisms of 240 pediatric ALL cases with their matched remission samples and gives insights into the molecular pathogenesis of this disease.
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ELMER v.2: an R/Bioconductor package to reconstruct gene regulatory networks from DNA methylation and transcriptome profiles.
Tiago C. Silva,Tiago C. Silva,Simon G. Coetzee,Nicole Gull,Lijing Yao,Dennis J. Hazelett,Houtan Noushmehr,Houtan Noushmehr,De-Chen Lin,Benjamin P. Berman +9 more
TL;DR: A completely revised version 2 of ELMER is presented that provides numerous new features including an optional web-based interface and a new Supervised Analysis mode to use pre-defined sample groupings and it is shown that Supervised mode significantly increases statistical power and identifies additional GRNs and associated Master Regulators, such as SOX11 and KLF5 in Basal-like breast cancer.
Journal ArticleDOI
Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia.
Haibo Sun,Haibo Sun,De-Chen Lin,Xiao Guo,Behzad Kharabi Masouleh,Sigal Gery,Qi Cao,Serhan Alkan,Takayuki Ikezoe,Chie Akiba,Ronald Paquette,Wenwen Chien,Carsten Müller-Tidow,Yang Jing,Konstantin Agelopoulos,Markus Müschen,H. Phillip Koeffler,H. Phillip Koeffler +17 more
TL;DR: It is shown that the expression of both mature and spliced forms of XBP1 (XBP1s) is up-regulated in acute myeloid leukemia (AML) cell lines and AML patient samples, and targeting IRE1α driven pro-survival pathways represent an exciting therapeutic approach for the treatment of AML.