N
Norihiko Kawamata
Researcher at Tokyo Medical and Dental University
Publications - 83
Citations - 5226
Norihiko Kawamata is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Gene & Loss of heterozygosity. The author has an hindex of 39, co-authored 83 publications receiving 5031 citations. Previous affiliations of Norihiko Kawamata include University of California, Los Angeles & Juntendo University.
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Journal ArticleDOI
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Masashi Sanada,Takahiro Suzuki,Lee-Yung Shih,Makoto Otsu,Motohiro Kato,Satoshi Yamazaki,Azusa Tamura,Hiroaki Honda,Mamiko Sakata-Yanagimoto,Keiki Kumano,Hideaki Oda,Tetsuya Yamagata,Junko Takita,Noriko Gotoh,Kumi Nakazaki,Norihiko Kawamata,Masafumi Onodera,Masaharu Nobuyoshi,Yasuhide Hayashi,Hiroshi Harada,Mineo Kurokawa,Shigeru Chiba,Hiraku Mori,Keiya Ozawa,Mitsuhiro Omine,Hisamaru Hirai,Hiromitsu Nakauchi,H. Phillip Koeffler,Seishi Ogawa +28 more
TL;DR: In this paper, gain-of-function mutations of the C-CBL (also known as CBL) tumour suppressor are tightly associated with acquired uniparental disomy (aUPD) in myeloid neoplasms showing myeloproliferative features.
Journal Article
Molecular Analysis of the Cyclin-dependent Kinase Inhibitor Gene p27/Kip1 in Human Malignancies
Norihiko Kawamata,R Morosetti,Carl W. Miller,Dorothy J. Park,K S Spirin,T Nakamaki,Seisho Takeuchi,Yoshihiro Hatta,J F Simpson,S Wilcyznski +9 more
TL;DR: Two groups of CDKIs are classified based on the structure of the proteins, including the p15, p16, and p18CDKIs, which have ankyrin repeat motifs, and the p27/Kip1 and p21 CDKI genes, which are rarely mutated in human malignancies.
Journal ArticleDOI
Highly Sensitive Method for Genomewide Detection of Allelic Composition in Nonpaired, Primary Tumor Specimens by Use of Affymetrix Single-Nucleotide–Polymorphism Genotyping Microarrays
Go Yamamoto,Yasuhito Nannya,Motohiro Kato,Masashi Sanada,Ross L. Levine,Norihiko Kawamata,Akira Hangaishi,Mineo Kurokawa,Shigeru Chiba,D. Gary Gilliland,H. Phillip Koeffler,Seishi Ogawa +11 more
TL;DR: A simple but highly sensitive method for genomewide detection of allelic composition, based on the Affymetrix single-nucleotide-polymorphism genotyping microarray platform, without dependence on the availability of constitutive DNA, is described and should substantially improve the ability to dissect the complexity of cancer genomes.
Journal ArticleDOI
Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk
Amy L. Sherborne,Fay J. Hosking,Rashmi B. Prasad,Rajesh Kumar,Rolf Koehler,Jayaram Vijayakrishnan,Elli Papaemmanuil,Claus R. Bartram,Martin Stanulla,Martin Schrappe,Andreas Gast,Sara E. Dobbins,Yussanne Ma,Eamonn Sheridan,Malcolm Taylor,Sally E. Kinsey,T Lightfoot,Eve Roman,Julie Irving,James M. Allan,Anthony V. Moorman,Christine J. Harrison,Ian Tomlinson,Sue Richards,Martin Zimmermann,Csaba Szalai,Ágnes F. Semsei,Dániel J. Erdélyi,Maja Krajinovic,Daniel Sinnett,Jasmine Healy,Anna Gonzalez Neira,Norihiko Kawamata,Seishi Ogawa,H. Phillip Koeffler,Kari Hemminki,Mel Greaves,Richard S. Houlston +37 more
TL;DR: Common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 × 10−11), irrespective of cell lineage.
Journal Article
Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high resolution single nucleotide polymorphism oligonucleotide microarray.
Norihiko Kawamata,Seishi Ogawa,Martin Zimmermann,Masashi Sanada,Kari Hemminki,Go Yamatomo,Yasuhito Nannya,Rolf Koehler,Thomas Flohr,Carl Miller,Jochen Harbott,Wolf-Dieter Ludwig,Martin Stanulla,Martin Schrappe,Claus R. Bartram,Phillip Koeffler +15 more
TL;DR: In this paper, the authors used high resolution single-nucleotide polymorphism microarray (SNP-Chip) technique to detect genomic abnormalities in ALL patients, including deletion of ETV6, deletion of P16INK4A and hyperdiploidy.