D
De-Chen Lin
Researcher at Cedars-Sinai Medical Center
Publications - 119
Citations - 7530
De-Chen Lin is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Cancer & Epigenomics. The author has an hindex of 36, co-authored 105 publications receiving 4614 citations. Previous affiliations of De-Chen Lin include Sun Yat-sen University & Peking Union Medical College.
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Journal ArticleDOI
SEanalysis: a web tool for super-enhancer associated regulatory analysis.
Fengcui Qian,Xuecang Li,Jin-Cheng Guo,Jianmei Zhao,Yanyu Li,Zhidong Tang,Li-Wei Zhou,Jian Zhang,Xuefeng Bai,Yong Jiang,Qi Pan,Qiuyu Wang,Qiuyu Wang,En-Min Li,Chunquan Li,Li-Yan Xu,De-Chen Lin +16 more
TL;DR: A novel web server, SEanalysis, is designed, which provides comprehensive SE-associated regulatory network analyses and developed a customizable genome browser containing >6000 customizable tracks for visualization.
Journal ArticleDOI
Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma
Rui You,You-Ping Liu,De-Chen Lin,Qing X. Li,Tao Yu,Xiong Zou,Mei Lin,Xiaolong Zhang,Gui-Ping He,Qi Yang,Yi-Nuan Zhang,Yu-Long Xie,Rou Jiang,Chen-Yan Wu,Chao Zhang,Cheng Cui,Jing-Qi Wang,Yue Wang,Ai-Hua Zhuang,Gui-Fang Guo,Yi-Jun Hua,Rui Sun,Jing-Ping Yun,Zhixiang Zuo,Zexian Liu,Xiao Feng Zhu,Tiebang Kang,Chao-Nan Qian,Hai-Qiang Mai,Ying Sun,Mu Sheng Zeng,Lin Feng,Yi Xin Zeng,Ming-Yuan Chen +33 more
TL;DR: NPC and pNPC tissues had similar mutational burdens, however, the number of clonal mutations was increased in rNPC samples, and nuclear accumulation of NF-κB is a prominent biomarker for predicting locoregional relapse-free survival.
Journal ArticleDOI
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer.
Li Yan Li,Li Yan Li,Qian Yang,Yan-Yi Jiang,Wei Yang,Yuan Jiang,Xiang Li,Masaharu Hazawa,Bo Zhou,Guowei Huang,Xiu E. Xu,Sigal Gery,Ying Zhang,Ling-Wen Ding,Allen S. Ho,Zachary S. Zumsteg,Ming Rong Wang,Melissa J. Fullwood,Stephen J. Freedland,Stephen J. Meltzer,Li Yan Xu,En Min Li,H. Phillip Koeffler,De-Chen Lin +23 more
TL;DR: In this article, the sterol regulatory element binding transcription factor 1 (SREBF1) was identified as a central mediator linking tumor protein p63 with fatty acid metabolism, which regulates the biosynthesis of fatty acid, sphingolipids (SL), and glycerophospholipid (GPL), as revealed by liquid chromatography tandem mass spectrometry (LC-MS/MS)-based lipidomics.
Journal ArticleDOI
RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling.
Xin-Yi Loh,Qiao-Yang Sun,Ling-Wen Ding,Anand Mayakonda,Nachiyappan Venkatachalam,Mei-Shi Yeo,Tiago C. Silva,Tiago C. Silva,Jin-Fen Xiao,Ngan B. Doan,Jonathan W. Said,Xue-Bin Ran,Siqin Zhou,Pushkar Dakle,Pavithra Shyamsunder,Angele Pei-Fern Koh,Ruby Yun-Ju Huang,Benjamin P. Berman,Benjamin P. Berman,Soo Yong Tan,Henry Yang,De-Chen Lin,H. Phillip Koeffler,H. Phillip Koeffler +23 more
TL;DR: Findings reveal an indispensable role of ZFP36L1 as a posttranscriptional safeguard against aberrant hypoxic signaling and abnormal cell cycle progression.
Posted ContentDOI
Predicting master transcription factors from pan-cancer expression data
Jessica Reddy,Marcos A. S. Fonseca,Rosario I. Corona,Robbin Nameki,Felipe Segato Dezem,Isaac A. Klein,Heidi Chang,Daniele Chaves-Moreira,Lena K. Afeyan,Tathiane M. Malta,Xianzhi Lin,Forough Abbasi,Alba Font-Tello,Thais S. Sabedot,Paloma Cejas,Norma Rodriguez-Malave,Ji-Heui Seo,De-Chen Lin,Ursula A. Matulonis,Beth Y. Karlan,Simon A. Gayther,Alexander Gusev,Houtan Noushmehr,Henry Long,Matthew L. Freedman,Ronny Drapkin,Brian J. Abraham,Richard A. Young,Kate Lawrenson +28 more
TL;DR: A predictive algorithm called CaCTS (Cancer Core Transcription factor Specificity) is developed to identify candidate MTFs using pan-cancer RNA-sequencing data from The Cancer Genome Atlas, suggesting early down-regulation of these genes may be responsible for cytotoxic effects of THZ1 on HGSOC models.