D
De-Chen Lin
Researcher at Cedars-Sinai Medical Center
Publications - 119
Citations - 7530
De-Chen Lin is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Cancer & Epigenomics. The author has an hindex of 36, co-authored 105 publications receiving 4614 citations. Previous affiliations of De-Chen Lin include Sun Yat-sen University & Peking Union Medical College.
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Journal ArticleDOI
SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway
Qiao-Yang Sun,Ling-Wen Ding,Jin-Fen Xiao,Wenwen Chien,Su Lin Lim,Norimichi Hattori,Lee Goodglick,David Chia,Vei Mah,Mohammad Alavi,Sara R. Kim,Ngan B. Doan,Jonathan W. Said,Xin-Yi Loh,Liang Xu,Li-Zhen Liu,Henry Yang,Takahide Hayano,Shuo Shi,Dong Xie,De-Chen Lin,De-Chen Lin,H. Phillip Koeffler,H. Phillip Koeffler +23 more
TL;DR: In this article, the authors investigated the oncogenic role of SETDB1, focusing on non-small cell lung cancer (NSCLC) which has high expression of this protein.
Journal ArticleDOI
Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma.
Li Chen,Moli Huang,Jasmine T. Plummer,Jian Pan,Yan-Yi Jiang,Qian Yang,Tiago C. Silva,Nicole Gull,Stephanie Chen,Ling-Wen Ding,Omer An,Henry Yang,Yulan Cheng,Jonathan W. Said,Ngan B. Doan,Winand N.M. Dinjens,Kevin M. Waters,Richard Tuli,Simon A. Gayther,Samuel J. Klempner,Benjamin P. Berman,Stephen J. Meltzer,De-Chen Lin,H. Phillip Koeffler +23 more
TL;DR: By establishing cancer-specific and subtype-specific features of the EAC epigenome, the findings promise to transform understanding of the transcriptional dysregulation and addiction of EAC, while providing molecular clues to develop novel therapeutic modalities against this malignancy.
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BCL6 promotes glioma and serves as a therapeutic target.
Liang Xu,Ye Chen,Marina Dutra-Clarke,Anand Mayakonda,Masaharu Hazawa,Steve E. Savinoff,Ngan B. Doan,Jonathan W. Said,William H. Yong,Ashley Watkins,Henry Yang,Ling-Wen Ding,Yan-Yi Jiang,Jeffrey W. Tyner,Jianhong Ching,Jean-Paul Kovalik,Vikas Madan,Shing Leng Chan,Markus Müschen,Joshua J. Breunig,Joshua J. Breunig,De-Chen Lin,De-Chen Lin,H. Phillip Koeffler,H. Phillip Koeffler +24 more
TL;DR: It is demonstrated that BCL6 is a prognostic marker and a targetable GBM-promoting factor and that Bcl6 overexpression is associated with worse prognosis and the results highlight the promise and merit of targeting BCL 6 for treating this deadly disease.
Journal ArticleDOI
Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers.
De-Chen Lin,De-Chen Lin,Liang Xu,Ling-Wen Ding,Arjun Sharma,Li Zhen Liu,Henry Yang,Patrick Tan,Jay Vadgama,Beth Y. Karlan,Jenny Lester,Nicole Urban,Michèl Schummer,Ngan B. Doan,Jonathan W. Said,Hongmao Sun,Martin J. Walsh,Craig J. Thomas,Paresma R. Patel,Dong Yin,Danny Chan,H. Phillip Koeffler,H. Phillip Koeffler +22 more
TL;DR: Results suggest that although targeted by genomic homozygous microdeletions, PDE4D functions as a tumor-promoting factor and represents a unique targetable enzyme of cancer cells.
Journal ArticleDOI
ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation.
Masaharu Hazawa,De-Chen Lin,De-Chen Lin,Akiko Kobayashi,Yan-Yi Jiang,Liang Xu,Firli Rahmah Primula Dewi,Mahmoud Shaaban Mohamed,Hartono,Mitsutoshi Nakada,Makiko Meguro-Horike,Shin-ichi Horike,H. Phillip Koeffler,H. Phillip Koeffler,Richard W. Wong +14 more
TL;DR: NUP62 is characterized as a gatekeeper for ΔNp63α and its role in the control of cell fate through regulation of ΔN p63α nuclear transport in SCC is uncovered.