T
Tobias Weinert
Researcher at Paul Scherrer Institute
Publications - 42
Citations - 1793
Tobias Weinert is an academic researcher from Paul Scherrer Institute. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 18, co-authored 33 publications receiving 1221 citations. Previous affiliations of Tobias Weinert include Max Planck Society.
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Journal ArticleDOI
Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser
Przemyslaw Nogly,Tobias Weinert,Daniel James,Sergio Carbajo,Dmitry Ozerov,Antonia Furrer,Dardan Gashi,Veniamin Borin,Petr Skopintsev,Kathrin Jaeger,Karol Nass,Petra Båth,Robert Bosman,Jason E. Koglin,Matthew Seaberg,Thomas J. Lane,Demet Kekilli,Steffen Brünle,Tomoyuki Tanaka,Wenting Wu,Christopher J. Milne,Thomas P. White,Anton Barty,Uwe Weierstall,Valerie Panneels,Eriko Nango,So Iwata,Mark S. Hunter,Igor Schapiro,Gebhard F. X. Schertler,Gebhard F. X. Schertler,Richard Neutze,Jörg Standfuss +32 more
TL;DR: The principal mechanism of isomerization in this prototypical retinal-binding protein has direct relevance for all other members of this important family of membrane proteins, and it provides insight into how protein environments catalyze photochemical reactions in general.
Journal ArticleDOI
Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Tobias Weinert,Natacha Olieric,Robert K. Y. Cheng,Steffen Brünle,Daniel James,Dmitry Ozerov,Dardan Gashi,Laura Vera,May Marsh,Kathrin Jaeger,Florian S. N. Dworkowski,Ezequiel Panepucci,Shibom Basu,Petr Skopintsev,Andrew S. Doré,T. Geng,Robert M. Cooke,Mengning Liang,Andrea E. Prota,Valerie Panneels,Przemyslaw Nogly,Ulrich Ermler,Gebhard F. X. Schertler,Gebhard F. X. Schertler,Michael Hennig,Michel O. Steinmetz,Michel O. Steinmetz,Meitian Wang,Jörg Standfuss +28 more
TL;DR: It is demonstrated that serial millisecond crystallography at a synchrotron beamline equipped with high-viscosity injector and high frame-rate detector allows typical crystallographic experiments to be performed at room-temperature.
Journal ArticleDOI
Structure of a methyl-coenzyme M reductase from Black Sea mats that oxidize methane anaerobically
Seigo Shima,Martin Krueger,Tobias Weinert,Ulrike Demmer,Jörg Kahnt,Rudolf K. Thauer,Ulrich Ermler +6 more
TL;DR: An X-ray structure of the 280 kDa heterohexameric ANME-1 MCR complex is reported, indicating the same substrates for MCR from methanotrophic and methanogenic archaea.
Journal ArticleDOI
Fast native-SAD phasing for routine macromolecular structure determination.
Tobias Weinert,Vincent Olieric,Sandro Waltersperger,Ezequiel Panepucci,Lirong Chen,Hua Zhang,Dayong Zhou,John Rose,Akio Ebihara,Seiki Kuramitsu,Dianfan Li,Nicole Howe,Gisela Schnapp,Alexander Pautsch,Katja Bargsten,Andrea E. Prota,Parag Surana,Jithesh Kottur,Deepak T. Nair,Federica Basilico,Valentina Cecatiello,Sebastiano Pasqualato,Andreas Boland,Oliver Weichenrieder,Bi-Cheng Wang,Michel O. Steinmetz,Martin Caffrey,Meitian Wang +27 more
TL;DR: A data collection method that uses a single crystal to solve X-ray structures by native SAD (single-wavelength anomalous diffraction) and solved the structures of 11 real-life examples, including a human membrane protein, a protein-DNA complex and a 266-kDa multiprotein-ligand complex.
ComponentDOI
Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography.
Tobias Weinert,Petr Skopintsev,Daniel James,Florian S. N. Dworkowski,Ezequiel Panepucci,Demet Kekilli,Antonia Furrer,Steffen Brünle,S. Mous,Dmitry Ozerov,Przemyslaw Nogly,Meitian Wang,Jörg Standfuss +12 more
TL;DR: In this article, the structural changes in the light-driven proton-pump bacteriorhodopsin over 200 milliseconds in time were recorded using synchrotrons.