Kathrin Jaeger

TL;DR: The principal mechanism of isomerization in this prototypical retinal-binding protein has direct relevance for all other members of this important family of membrane proteins, and it provides insight into how protein environments catalyze photochemical reactions in general.

TL;DR: It is demonstrated that serial millisecond crystallography at a synchrotron beamline equipped with high-viscosity injector and high frame-rate detector allows typical crystallographic experiments to be performed at room-temperature.

TL;DR: The structure determination of a membrane protein is described by serial injection of microcrystals in lipidic cubic phases into a synchrotron microfocus beam with respect to serial femtosecond crystallography at free-electron lasers.

TL;DR: The crystal structure of human CCR7 fused to the protein Sialidase NanA is presented by using data up to 2.1 Å resolution and it is demonstrated how structural data can be used in combination with a compound repository and automated thermal stability screening to identify and modulate allosteric chemokine receptor antagonists.

TL;DR: The strategies towards structural dynamic studies of retinal proteins at room temperature, using injector or fixed-target based serial femtosecond crystallography at X-FELs are described.