Dmitry Ozerov

TL;DR: The principal mechanism of isomerization in this prototypical retinal-binding protein has direct relevance for all other members of this important family of membrane proteins, and it provides insight into how protein environments catalyze photochemical reactions in general.

TL;DR: It is demonstrated that serial millisecond crystallography at a synchrotron beamline equipped with high-viscosity injector and high frame-rate detector allows typical crystallographic experiments to be performed at room-temperature.

TL;DR: In this article, the structural changes in the light-driven proton-pump bacteriorhodopsin over 200 milliseconds in time were recorded using synchrotrons.

TL;DR: Crystallographic ‘snapshots’ taken at intervals of femtoseconds to milliseconds after activation show how a light-activated sodium pump carries sodium ions across the cell membrane and provide direct molecular insight into the dynamics of active cation transport across biological membranes.

TL;DR: The application of a direct-detection charge-integrating pixel-array detector (JUNGFRAU) in macromolecular crystallography (MX) that features a uniform response on the subpixel level, linear behavior toward high photon rates, and low-noise performance across the whole dynamic range is described.