L
Laurence Huang
Researcher at University of California, San Francisco
Publications - 251
Citations - 12513
Laurence Huang is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Tuberculosis & Pneumocystis pneumonia. The author has an hindex of 57, co-authored 236 publications receiving 11269 citations. Previous affiliations of Laurence Huang include San Francisco General Hospital & University of Maryland, Baltimore.
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Journal ArticleDOI
Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study
Catharina Boehme,Mark P. Nicol,Mark P. Nicol,Pamela Nabeta,Joy Sarojini Michael,Eduardo Gotuzzo,Rasim Tahirli,Ma Tarcela Gler,Robert Blakemore,William Worodria,Christen Gray,Laurence Huang,Tatiana Cáceres,Rafail Mehdiyev,Lawrence Raymond,Andrew Whitelaw,Andrew Whitelaw,Kalaiselvan Sagadevan,Heather Alexander,Heather Alexander,Heidi Albert,Frank Cobelens,Helen M Cox,David Alland,Mark D. Perkins +24 more
TL;DR: The Xpert MTB/RIF test can effectively be used in low-resource settings to simplify patients' access to early and accurate diagnosis, thereby potentially decreasing morbidity associated with diagnostic delay, dropout and mistreatment.
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Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers
Alison Morris,James M. Beck,Patrick D. Schloss,Thomas B. Campbell,Kristina Crothers,Jeffrey L. Curtis,Sonia C. Flores,Andrew P. Fontenot,Elodie Ghedin,Laurence Huang,Kathleen A. Jablonski,Eric C. Kleerup,Susan V. Lynch,Erica Sodergren,Homer L. Twigg,Vincent B. Young,Christine M. Bassis,Arvind Venkataraman,Thomas M. Schmidt,George M. Weinstock +19 more
TL;DR: This study is the largest to examine composition of the lower respiratory tract microbiome in healthy individuals and the first to use the neutral model to compare the lung to the mouth, demonstrating that the lung microbiome does not derive entirely from the mouth.
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Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients.
Vassili Soumelis,Iain Scott,Ferdous Gheyas,Damien Bouhour,Gregoire Cozon,Laurent Cotte,Laurence Huang,Jay A. Levy,Yong-Jun Liu +8 more
TL;DR: This study provides the first evidence that IPCs are being affected during the course of HIV infection and suggests that these cells can play a vital role in the protection against opportunistic pathogens and cancer.
Journal ArticleDOI
Current epidemiology of Pneumocystis pneumonia.
Alison Morris,Jens D Lundgren,Henry Masur,Peter D. Walzer,Debra L. Hanson,Toni Frederick,Laurence Huang,Charles B. Beard,Jonathan E. Kaplan +8 more
TL;DR: Changes in incidence of PCP, groups at risk forPCP, and possible trends in the disease are discussed.
Journal ArticleDOI
Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype.
Leopoldo N. Segal,Jose C. Clemente,Jun Chieh J. Tsay,Sergei B. Koralov,Brian C. Keller,Benjamin G. Wu,Yonghua Li,Nan Shen,Elodie Ghedin,Alison Morris,P. Diaz,Laurence Huang,William R. Wikoff,Carles Ubeda,Alejandro Artacho,William N. Rom,Daniel H. Sterman,Ronald G. Collman,Martin J. Blaser,Michael D. Weiden +19 more
TL;DR: P pneumotypeSPT was associated with a distinct metabolic profile, enhanced expression of inflammatory cytokines, a pro-inflammatory phenotype characterized by elevated Th-17 lymphocytes and, conversely, a blunted alveolar macrophage TLR4 response.